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Review Article

靶向肿瘤免疫治疗中的CXCL12 / CXCR4轴

卷 26, 期 17, 2019

页: [3026 - 3041] 页: 16

弟呕挨: 10.2174/0929867324666170830111531

价格: $65

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摘要

具有趋化能力的趋化因子由具有8-10千道尔顿的小细胞因子家族组成。 趋化因子通过运输和调节细胞增殖，迁移，活化，分化和归巢在免疫细胞中起作用。 CXCR-4是特异于基质衍生因子-1（SDF-1，也称为CXCL12）的α-趋化因子受体，已发现其在超过23种不同类型的癌症中表达。 最近，SDF-1 / CXCR-4信号通路已成为人类肿瘤的潜在治疗靶点，因为它通过激活多种信号通路在肿瘤的发生和发展中发挥关键作用，如ERK1 / 2，ras，p38 MAPK，PLC / MAPK和SAPK / JNK，以及调节癌症干细胞。 已经产生了CXCL12 / CXCR4拮抗剂，其已显示出令人鼓舞的抗癌活性结果。 在这里，我们简要概述了CXCL12 / CXCR4轴作为癌症治疗的分子靶点。 我们还根据最新文献和正在进行的研究进展，回顾了靶向CXCL12 / CXCR4轴与免疫疗法和/或化学疗法相结合的潜在效用。

关键词: 癌症，癌症干细胞，免疫疗法，CXCR4，CXCL12，趋化因子，千道尔顿。

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