摘要
熊果酸是一种天然的五环三萜，常见于具有良好生物学和药理活性的植物和食品中。 该化合物由于其通过低毒性的不同途径抑制肿瘤细胞的分化，血管生成，侵袭和转移而具有相当大的抗癌作用而受到研究人员的关注。 由于化合物在水中的溶解性差，熊果酸的生物利用度差。 熊果酸的低生物利用度和短血浆半衰期以及体内的非特异性分布被认为是化合物治疗开发中的障碍。 纳米药物递送系统可以改善一些药物的药代动力学，生物利用度和治疗活性。 本综述重点关注在癌症治疗中关于熊果酸的纳米药物递送系统的最新发展。
关键词: 生物利用度，癌症，纳米医学，天然化合物，熊果酸，综述。
Call for Papers in Thematic Issues
Advances in Medicinal Chemistry: From Cancer to Chronic Diseases.
The broad spectrum of the issue will provide a comprehensive overview of emerging trends, novel therapeutic interventions, and translational insights that impact modern medicine. The primary focus will be diseases of global concern, including cancer, chronic pain, metabolic disorders, and autoimmune conditions, providing a broad overview of the advancements in ...read more
Approaches to the Treatment of Chronic Inflammation
Chronic inflammation is a hallmark of numerous diseases, significantly impacting global health. Although chronic inflammation is a hot topic, not much has been written about approaches to its treatment. This thematic issue aims to showcase the latest advancements in chronic inflammation treatment and foster discussion on future directions in this ...read more
Cellular and Molecular Mechanisms of Non-Infectious Inflammatory Diseases: Focus on Clinical Implications
The Special Issue covers the results of the studies on cellular and molecular mechanisms of non-infectious inflammatory diseases, in particular, autoimmune rheumatic diseases, atherosclerotic cardiovascular disease and other age-related disorders such as type II diabetes, cancer, neurodegenerative disorders, etc. Review and research articles as well as methodology papers that summarize ...read more
Chalcogen-modified nucleic acid analogues
Chalcogen-modified nucleosides, nucleotides and oligonucleotides have been of great interest to scientific research for many years. The replacement of oxygen in the nucleobase, sugar or phosphate backbone by chalcogen atoms (sulfur, selenium, tellurium) gives these biomolecules unique properties resulting from their altered physical and chemical properties. The continuing interest in ...read more
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