摘要
背景：Thymoquinone（TQ）是一种生物活性植物成分，由黑种（Nigella sativa）（黑种子）获得。它在预防癌症方面具有潜力。 目的：以前的研究表明，TQ可以调节负责癌症进展的信号通路，从而提高临床使用的抗癌药物的功效和改善安全性。 方法：TQ作用于细胞周期，通过靶向各种蛋白质（细胞周期蛋白D1，细胞周期蛋白E和p27）抑制从G1向S期的进展。它还表现出组蛋白去乙酰化酶（HDAC）抑制作用，靶向p21和Maspin，并诱导促凋亡基因Bax和下调抗凋亡基因Bcl-2。据报道，乳腺癌（BC）是妇女最常见的恶性肿瘤之一。结果：尽管研究和进步，它仍然是女性癌症相关死亡的最常见原因之一。 BC的分子筛选的最新进展导致鉴定三阴性乳腺癌（TNBC）的临床挑战性状况。 TNBC的特征是缺乏可靶向的受体，雌激素受体（ER），孕激素受体（PR）和人表皮生长因子受体2（HER2）的表达。其特征还在于磷酸酶和张力蛋白同系物（PTEN）表达的减少或缺失，所述肿瘤抑制基因具有调节细胞凋亡，细胞周期和转移的多种功能。 结论：由于已有报道TQ能够上调血管内皮生长因子（VEGF），EGF和PTEN表达等多种生长因子，因此本文综述了TQ对这类乳腺癌治疗干预的靶向潜能。
关键词: Thymoquinone，黑种子，HDAC，乳腺癌，TNBC，凋亡，VEGF。
图形摘要
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