Leishmanicidal and Trypanocidal Activity of Metal Complexes with 1,2,4-Triazolo[1,5-a]pyrimidines: Insights on their Therapeutic Potential against Leishmaniasis and Chagas Disease

doi:10.2174/0929867324666170516122024

摘要

自二十世纪初第一次合成以来，1,2,4-三唑并[1,5-a]嘧啶已经引起了越来越多的兴趣，从化学治疗到农业甚至是摄影。它们与嘌呤的相似性赋予潜在的生物活性，并且该功能已被明智地用于治疗用途，包括抗真菌，解热，镇痛，抗炎，抗肿瘤和抗寄生虫性质。在这次审查中，我们专注于这些氮杂环与金属离子形成的化合物及其对两种被忽视的热带流行病，利什曼病和恰加斯病疾病的抗寄生虫活性和治疗潜力。

关键词: 三唑并嘧啶，金属络合物，利什曼原虫，克氏锥虫，利什曼病，恰加斯病，被忽视的热带病。

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Current Medicinal Chemistry

Title:Leishmanicidal and Trypanocidal Activity of Metal Complexes with 1,2,4-Triazolo[1,5-a]pyrimidines: Insights on their Therapeutic Potential against Leishmaniasis and Chagas Disease

Volume: 24 Issue: 25

关键词: 三唑并嘧啶，金属络合物，利什曼原虫，克氏锥虫，利什曼病，恰加斯病，被忽视的热带病。

摘要: Since their first synthesis back in the early 20th century, 1,2,4-triazolo[1,5- a]pyrimidines have aroused increasing interest in very diverse areas ranging from chemotherapy to agriculture or even photography. Their similarity to purines confers a potential bioactivity and this feature has been wisely exploited for therapeutic use, including antifungal, antipyretic, analgesic, antiinflammatory, antitumoral and antiparasitic properties. In this review, we focus on the compounds that these nitrogen heterocycles form with metal ions and their antiparasitic activity and therapeutic potential against two neglected diseases of tropical prevalence, leishmaniasis and Chagas disease.

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Leishmanicidal and Trypanocidal Activity of Metal Complexes with 1,2,4-Triazolo[1,5-a]pyrimidines: Insights on their Therapeutic Potential against Leishmaniasis and Chagas Disease, Current Medicinal Chemistry 2017; 24 (25) . https://dx.doi.org/10.2174/0929867324666170516122024

DOI https://dx.doi.org/10.2174/0929867324666170516122024	Print ISSN 0929-8673
Publisher Name Bentham Science Publisher	Online ISSN 1875-533X

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