摘要
了解去势耐药前列腺癌的耐药机制。 背景：左旋脲(MDV 3100，XTANDI)是第二代雄激素受体抑制剂，专为治疗去势耐药前列腺癌(Crpc)而设计，具有较长的生存期。是时候了。MDV 3100耐药的机制尚不清楚，大多数接受治疗的患者，无论是先天的还是后天的，都会出现耐药性。 目的：本综述旨在总结MDV3100抗性机制中可用的主要数据。 了解所引起的阻力对und具有临床意义在日常实践和改进策略中，对预后和预测生物标志物的有效性进行了评价。 结果：MDV 3100的耐药主要可分为两种不同的途径，一是依赖于雄激素受体的活性，二是与雄激素受体的活性无关。雄激素受体(AR)轴位于第一位。前列腺癌细胞的重要通路，目前仍被认为是一种重要的耐药机制。 结论：靶向这些新识别的信号，尤其是AR轴，可能通过新的治疗剂潜在地克服，协同地改善CRPC中的ADT。
关键词: 去势抵抗性前列腺癌，enzalutamide，耐药性，雄激素受体，生物标志物，抑制剂。
图形摘要
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Advanced Pharmacy
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