肝细胞癌的溶瘤病毒治疗与基因治疗策略

Title:Oncolytic Virotherapy and Gene Therapy Strategies for Hepatobiliary Cancers

Volume: 18 Issue: 2

关键词: 基因治疗，胆囊癌，胆管癌，溶瘤病毒，腺病毒，病毒疗法。

摘要: Advanced liver cancers and biliary cancers represent diseases with dismal prognosis because of frequent local invasion and metastasis. Effective therapeutic agents for these cancers have not been established. Oncolytic viruses (OVs) constitute a novel class of promising, selective anticancer agents and recent studies have elucidated their unique features. Moreover, clinical trials are demonstrating promising results. Numerous OVs are being tested in preclinical models of hepatocellular carcinoma (HCC). The lead agent Pexa-Vec (pexastimogene devacirepvec, JX-594), a recombinant Wyeth strain vaccinia virus, has demonstrated preliminary evidence of safety and efficacy for HCC in clinical trials. Few other OVs have entered clinical testing. Relatively few preclinical studies and clinical trials exist for biliary cancers. In this review, we introduce various approaches using OVs to treat the intractable hepatobiliary cancers.

Cite this article as:

Oncolytic Virotherapy and Gene Therapy Strategies for Hepatobiliary Cancers, Current Cancer Drug Targets 2018; 18 (2) . https://dx.doi.org/10.2174/1568009617666170330123841