摘要
背景:最近的证据表明肥胖除了是心血管事件的危险因素外,也增加了老年痴呆症的风险。胰岛素抵抗在所有肥胖病例中都很常见,似乎是两种疾病之间的联系。肥胖通常与过多的脂肪和糖摄入有关,是胰岛素抵抗的一个临床前阶段,在这种情况下,营养干预可能产生最大的效果。 目的:通过这种方式,健康的生活方式能够防止肥胖相关的可改变的危险因素,如炎症、氧化应激和代谢紊乱,同时有益于保持认知和控制阿尔茨海默病。 方法:本文综述了有关营养物质和饮食模式与肥胖和阿尔茨海默病相关的大量研究文献。此外,简要介绍了分子机制参与肥胖引起的胰岛素抵抗和外周炎症和有缺陷的胰岛素信号途径的贡献,以及异位脂质堆积的阿尔茨海默氏症的发展通过脑部炎症,神经细胞的胰岛素抵抗,与认知功能障碍的老年痴呆症。 结果:这项工作涉及目前和新兴的药理学和非药物治疗肥胖,胰岛素抵抗和老年痴呆症的管理,认为它们作为具有共同的分子特征的疾病。 结论:本研究的结果证实了一些营养干预措施对于预防或延缓阿尔茨海默病和肥胖的同时发展的重要性。
关键词: 肥胖、老年痴呆症、2型糖尿病、胰岛素抵抗、预防、饮食、营养、保健品等
Current Alzheimer Research
Title:Defective Insulin Signalling, Mediated by Inflammation, Connects Obesity to Alzheimer Disease; Relevant Pharmacological Therapies and Preventive Dietary Interventions
Volume: 14 Issue: 8
关键词: 肥胖、老年痴呆症、2型糖尿病、胰岛素抵抗、预防、饮食、营养、保健品等
摘要: Background: Recent evidence suggests that obesity, besides being a risk factor for cardiovascular events, also increases the risk of Alzheimer’s disease. Insulin resistance is common in all cases of obesity and appears to be the linkage between both diseases. Obesity, often associated with excessive fat and sugar intake, represents a preclinical stage toward insulin resistance during which nutrition intervention is likely to have maximum effect.
Objective: In this way, healthy lifestyles lifetime to prevent obesity-related modifiable risk factors such as inflammation, oxidative stress and metabolic disorders could be simultaneously beneficial for preserving cognition and controlling the Alzheimer’s disease. Method: This review relates extensive research literature on facts linking nutrients and dietary patterns to obesity and Alzheimer’s disease. In addition briefly presents molecular mechanisms involved in obesity- induced insulin resistance and the contribution of peripheral inflammatory and defective insulin signalling pathways, as well as ectopic lipids accumulation to Alzheimer’s development through brain inflammation, neuronal insulin resistance, and cognitive dysfunction seen in Alzheimer’s disease. Results: The work relates current and emerging pharmacological and non-pharmacological therapies for the management of obesity, insulin resistance and Alzheimer’s considering them as disorders with common molecular features. Conclusion: The findings of this review validate the importance of some nutritional interventions as possible approach to prevent or delay simultaneously progression of Alzheimer’s disease and obesity.Export Options
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Cite this article as:
Defective Insulin Signalling, Mediated by Inflammation, Connects Obesity to Alzheimer Disease; Relevant Pharmacological Therapies and Preventive Dietary Interventions, Current Alzheimer Research 2017; 14 (8) . https://dx.doi.org/10.2174/1567205014666170316161848
DOI https://dx.doi.org/10.2174/1567205014666170316161848 |
Print ISSN 1567-2050 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5828 |
Call for Papers in Thematic Issues
New Advances in the Prevention, Diagnosis, Treatment, and Rehabilitation of Alzheimer's Disease
Aims and Scope: Introduction: Alzheimer's disease (AD) poses a significant global health challenge, with an increasing prevalence that demands concerted efforts to advance our understanding and strategies for prevention, diagnosis, treatment, and rehabilitation. This thematic issue aims to bring together cutting-edge research and innovative approaches from multidisciplinary perspectives to address ...read more
Diagnostic and therapeutic biomarkers of dementia
Dementia affects 18 million people worldwide. Dementia is a syndrome of symptoms caused by brain disease, usually chronic or progressive, clinically characterized by multiple impairments of higher cortical functions such as memory, thinking, orientation, and learning. In addition, in the course of dementia, cognitive deficits are observed, which often hinder ...read more
Early nutritional intervention and physical activity in the prevention of Alzheimer's disease and other dementias
The aim is to broaden the knowledge about the impact of the consumption of food ingredients, diet ingredients, methods of processing of food raw materials as well as the impact of composing of diets on the possibility of preventing Alzheimer's disease and other types of dementia at each stage of ...read more
Enhancing Alzheimer's Disease Diagnosis and Treatment Efficacy Prediction with Explainable AI, Radiomics, Biomarkers, and Multimodal Neuroimaging
The thematic issue, Enhancing Alzheimer's Disease Diagnosis and Treatment Efficacy Prediction with Explainable AI, Radiomics, Biomarkers, and Multimodal Neuroimaging, aims to bridge the gap between advanced computational techniques and clinical practice in Alzheimer’s disease research. Alzheimer’s disease poses significant challenges in early diagnosis, disease progression monitoring, and predicting treatment efficacy. ...read more
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