摘要
背景：人血清白蛋白（HSA）是人血清中最丰富的蛋白质。 它具有许多功能，其中之一是小疏水分子的运输，包括药物，毒素，营养素，激素和代谢物。 HSA具有与各种结构不同的化合物相互作用的能力。 当两种或多种化合物竞争结合到相同分子位点时，这种混杂的非特异性亲和力可导致由置换引起的浓度的突然变化。 目的：在定义给药方案时，考虑药物组合及其与HSA的结合是重要的，因为它可以直接影响药物的血液中游离，积极的浓度。 结论：在本文中，我们回顾了药物相互作用与HSA的位移潜力，可能发生的情况及其临床意义。 我们还提供设计减少与HSA结合的药物的指导方针。
关键词: 人血清白蛋白，药物置换，药代动力学相互作用，游离浓度，药物设计
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