Abstract
Background: 1,3-Dipolar azide-alkyne cycloaddition (AAC) reaction, often referred to as click reaction, is an expeditious and robust protocol for the construction of triazole derivatives. In most cases, the reaction is catalyzed by a copper catalyst.
Methods: Non-conventional microwave heating has been used for the reaction showing ample advantages over the conventional thermal heating. Conclusion: This article has presented an overview on the recent advances in the area of microwave- induced AAC reactions in the presence of both homogeneous and heterogeneous copper catalysts, besides a few examples of Ru-catalyzed as well as metal-free AAC reactions.Keywords: Azide-alkyne cycloaddition (AAC), microwave irradiation (MW), 1, 2, 3-triazole, regioisomer, copper catalyst, metal-free, triazole synthesis.
Graphical Abstract
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