摘要
背景：尽管可以转录多达90％的真核基因组，但只有1-2％的所得转录本编码蛋白质，而其余的可以分类为非编码RNA（ncRNA），其主要由长ncRNA（lncRNAs）组成）和小ncRNAs。总体来说，他们被建议针对基因组中的特定区域，并在许多重要的生物过程中发挥多方面的作用。 总结：最近的证据表明，ncRNAs在脑中大量表达，其中许多在神经障碍中被异常调节。然而，它们在相关生理和病理过程中的功能相关性尚未得到充分的了解。因此，阐明ncRNA在脑中的作用将大大增强目前对神经发育的认识，最终导致治疗神经疾病的新策略。在本报告中，我们回顾了lncRNAs和各种类型的小ncRNAs在脑发育和神经障碍中的结构和机制。 观点：我们希望对这些ncRNA的广泛研究将揭示和表征脑中的新型分子电路，并促进为患有神经障碍的人开发基于RNA的治疗剂。
关键词: lncRNA，miRNA，piRNA，碱基配对，脑发育，神经障碍。
Call for Papers in Thematic Issues
Advances in Medicinal Chemistry: From Cancer to Chronic Diseases.
The broad spectrum of the issue will provide a comprehensive overview of emerging trends, novel therapeutic interventions, and translational insights that impact modern medicine. The primary focus will be diseases of global concern, including cancer, chronic pain, metabolic disorders, and autoimmune conditions, providing a broad overview of the advancements in ...read more
Approaches to the Treatment of Chronic Inflammation
Chronic inflammation is a hallmark of numerous diseases, significantly impacting global health. Although chronic inflammation is a hot topic, not much has been written about approaches to its treatment. This thematic issue aims to showcase the latest advancements in chronic inflammation treatment and foster discussion on future directions in this ...read more
Cellular and Molecular Mechanisms of Non-Infectious Inflammatory Diseases: Focus on Clinical Implications
The Special Issue covers the results of the studies on cellular and molecular mechanisms of non-infectious inflammatory diseases, in particular, autoimmune rheumatic diseases, atherosclerotic cardiovascular disease and other age-related disorders such as type II diabetes, cancer, neurodegenerative disorders, etc. Review and research articles as well as methodology papers that summarize ...read more
Chalcogen-modified nucleic acid analogues
Chalcogen-modified nucleosides, nucleotides and oligonucleotides have been of great interest to scientific research for many years. The replacement of oxygen in the nucleobase, sugar or phosphate backbone by chalcogen atoms (sulfur, selenium, tellurium) gives these biomolecules unique properties resulting from their altered physical and chemical properties. The continuing interest in ...read more
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