摘要
背景:人们普遍认为慢性炎症对癌症有重要的促进作用。癌症的免疫耐受介导肿瘤逃离免疫系统。炎症与免疫耐受关系的机制尚不完全阐明。 目的:本文考虑到炎症和耐受的主要机制,讨论了用于干预癌症炎症的药物靶点。 结论:炎症介导肿瘤诱导耐受。慢性炎症反应的诱导和维持是免疫耐受的普遍机制。
关键词: 炎症,分辨率,免疫耐受,肿瘤免疫治疗,肿瘤免疫,肿瘤诱导耐受。
Current Cancer Drug Targets
Title:The Linkage Between Inflammation and Immune Tolerance: Interfering with Inflammation in Cancer
Volume: 17 Issue: 4
关键词: 炎症,分辨率,免疫耐受,肿瘤免疫治疗,肿瘤免疫,肿瘤诱导耐受。
摘要: Background: It is widely accepted that chronic inflammation critically contributes to cancer. Immune tolerance in cancer mediates tumor escape from the immune system. The mechanisms of relations between inflammation and immune tolerance are still not fully elucidated.
Objective: The main mechanisms that link inflammation and tolerance are considered. Drug targets that are in use to interfere with inflammation in cancer are discussed. Conclusion: Inflammation mediates tumor-induced tolerance. The induction and the maintenance of the chronic inflammatory response is a universal mechanism of immune tolerance.Export Options
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Cite this article as:
The Linkage Between Inflammation and Immune Tolerance: Interfering with Inflammation in Cancer, Current Cancer Drug Targets 2017; 17 (4) . https://dx.doi.org/10.2174/1568009617666170109110816
DOI https://dx.doi.org/10.2174/1568009617666170109110816 |
Print ISSN 1568-0096 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-5576 |
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