摘要
神经胶质瘤是最常见的原发性恶性脑肿瘤，它具有普遍的致命后果。目前对神经胶质瘤患者的标准治疗是手术切除，其次是放射治疗和辅助化疗。由于治疗的耐药性和肿瘤复发，目前正在努力确定哪些分子是控制肿瘤进展的基本分子，并为神经胶质瘤患者的个体治疗提供了额外的方法。通过研究神经胶质瘤的启动和维护，研究重点是酪氨酸激酶受体的目标，包括表皮生长因子受体、PDGFR和其他重要的信号通路，如pi3k/akt和ras/raf/mapk路径。此外，最近在免疫治疗和干细胞治疗方面的进展也为神经胶质瘤治疗带来了许多策略。本文综述了各种目标治疗方法的研究进展，以提高神经胶质瘤治疗的疗效，并讨论了神经胶质瘤治疗的挑战和未来方向。
关键词: 神经胶质瘤、临床试验、靶向治疗、细胞信号转导通路、神经胶质瘤干细胞、免疫治疗。
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Chalcogen-modified nucleosides, nucleotides and oligonucleotides have been of great interest to scientific research for many years. The replacement of oxygen in the nucleobase, sugar or phosphate backbone by chalcogen atoms (sulfur, selenium, tellurium) gives these biomolecules unique properties resulting from their altered physical and chemical properties. The continuing interest in ...read more
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