摘要
背景：丹参具有不同的抗癌特性，这归因于其二萜和酚的含量。关于丹参成分的抗癌多样性和分子靶点没有全面的综述。 目的：研究丹参植物代谢物的多样性和分子靶点，负责预防和治疗癌症和肉瘤。 结果与结论：传统的治疗知识表明，丹参种类可用于开发抗癌药物。对丹参酮（Tan）IIA和隐丹参酮已经提出了许多担忧。一些丹参化合物干扰细胞周期，诱导肿瘤细胞凋亡或增强免疫活性，另一些则抑制增殖，侵袭，血管生成和转移，或逆转癌细胞的多药耐药性。丹参植物代谢产物调节Hanahan和Weinberg定义的大多数癌症标志。同一类植物代谢物可以通过多种途径发挥抗癌活性。已经揭示了一些植物代谢物的ADME / T性质和药物代谢动力学的外观。荧光探针是筛选来自Salvia植物代谢物的药物代谢酶/转运蛋白的底物，抑制剂或诱导剂的有力工具。 Omics平台将大大有助于从丹参植物中挖掘更多潜在有用的植物代谢物。更多的丹参植物在制药工业和临床癌症治疗中具有应用潜力。
关键词: 丹参，萜烯，酚类，抗癌多样性，组学，药物靶点。
图形摘要
Call for Papers in Thematic Issues
Drug-Targeted Approach with Polymer Nanocomposites for Improved Therapeutics
Polymer nanocomposites have been recognized as an advanced and cutting-edge technique in drug targeting administration. These materials combine the unique features of nanoparticles with the adaptability of polymers to produce highly personalized drug administration devices. Integrating nanoparticles containing pharmaceuticals into a polymer matrix enables researchers to regulate the rates at ...read more
New drug therapy for eye diseases
Eyesight is one of the most critical senses, accounting for over 80% of our perceptions. Our quality of life might be significantly affected by eye disease, including glaucoma, diabetic retinopathy, dry eye, etc. Although the development of microinvasive ocular surgery reduces surgical complications and improves overall outcomes, medication therapy is ...read more
Therapeutic Chemical and RNA Design with Artificial Intelligence
Computer-Aided Drug Design (CADD) has emerged as a fundamental component of modern drug discovery. Molecular docking facilitates virtual screening on a large scale through structural simulations. However, traditional CADD approaches face significant limitations, as they can only screen known compounds from existing libraries. PubChem, as the most widely used chemical ...read more
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Advanced Pharmacy
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