摘要
本综述详细介绍了2015年发布的新型海洋化合物及其合成类似物的最新结构 - 活性关系（SAR）研究，这些化合物具有潜在的或已建立的抗癌活性。作为抗癌药物发现过程的第一步，优先考虑通常使用人类癌细胞系组进行的海洋生物活性化合物体外筛选方法的论文。我们的综述描述了属于不同种类物质的化合物，即萜类化合物，糖苷，生物碱，类固醇以及其他小分子化合物。我们相信，我们的审查不仅将有助于化学家设计和合成在人类癌细胞中具有特异性细胞毒性或细胞抑制活性的新型抗癌化合物，而且还将扩展包括海洋天然化合物生物活性数据的现有数据库。
关键词: 海洋天然化合物，抗癌活性，结构 - 活性关系（SAR）研究，生物碱，甙类，萜类化合物，类固醇。
Call for Papers in Thematic Issues
Advances in Medicinal Chemistry: From Cancer to Chronic Diseases.
The broad spectrum of the issue will provide a comprehensive overview of emerging trends, novel therapeutic interventions, and translational insights that impact modern medicine. The primary focus will be diseases of global concern, including cancer, chronic pain, metabolic disorders, and autoimmune conditions, providing a broad overview of the advancements in ...read more
Approaches to the Treatment of Chronic Inflammation
Chronic inflammation is a hallmark of numerous diseases, significantly impacting global health. Although chronic inflammation is a hot topic, not much has been written about approaches to its treatment. This thematic issue aims to showcase the latest advancements in chronic inflammation treatment and foster discussion on future directions in this ...read more
Cellular and Molecular Mechanisms of Non-Infectious Inflammatory Diseases: Focus on Clinical Implications
The Special Issue covers the results of the studies on cellular and molecular mechanisms of non-infectious inflammatory diseases, in particular, autoimmune rheumatic diseases, atherosclerotic cardiovascular disease and other age-related disorders such as type II diabetes, cancer, neurodegenerative disorders, etc. Review and research articles as well as methodology papers that summarize ...read more
Chalcogen-modified nucleic acid analogues
Chalcogen-modified nucleosides, nucleotides and oligonucleotides have been of great interest to scientific research for many years. The replacement of oxygen in the nucleobase, sugar or phosphate backbone by chalcogen atoms (sulfur, selenium, tellurium) gives these biomolecules unique properties resulting from their altered physical and chemical properties. The continuing interest in ...read more
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