摘要
背景：与其他疾病相比，心血管疾病（CVD）的全球死亡率最高。 与CVD相关的主要危险因素是高血压。 目前的抗高血压（AHT）疗法的主要类型包括血管紧张素转换酶抑制剂（ACEI），血管紧张素受体阻断剂（ARB）和钙通道阻滞剂（CCBs）。 所有这些抗高血压治疗药物具有低口服生物利用度，并且可以诱导上呼吸道抽取，血管性水肿，反射性心动过速和口服后极度的降血压作用，这可引起心脏病患者的致死作用。 目的：通过使用抗高血压药物进行控制和靶向释放可以提供更好的解决方案，克服上述副作用。 结果：开发基于生物聚合物的纳米载体系统的科学进化为安全和/或可食用的纳米药物递送系统开辟了新的视野。在本文中，我们详细回顾了AHT药物的各种机制，与目前的治疗策略相关的主要吸引力，以及AHT纳米药物与常规药物相比的优势。此外，最近有关具有不同AHT药物的生物基纳米/微载体系统的报告已经被分析了其主要特征。壳聚糖作为AHT药物的潜在携带者，由于其独特的性质，包括粘膜粘附性，渗透性以及其生物相容性和生物可降解性，已作深入回顾。 结论：基于壳聚糖的新型AHT纳米凝胶可以通过其在GIT下部的持续释放来改善口服生物利用度，降低疏水性并增加AHT药物的血浆半衰期。
关键词: 纳米载体系统，高血压，抗高血压治疗，壳聚糖纳米颗粒，ACE抑制剂，药物递送。
图形摘要
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