Abstract
This review highlights recent advances in the preparation of silica nanoparticles (SNPs) functionalized with porphyrins and phthalocyanines for application in cancer photodiagnostic and photodynamic therapy (PDT). The use of photosensitizer-SNP formulations has emerged recently as a new nanomedicine for cancer research owing to their unique physicochemical properties, which make them useful for photo-biomedical applications. In order to study their photobiological properties, diverse chemical strategies involving covalent and non-covalent bonding have been used to load photosensitizers in/on SNPs.
Keywords: Porphyrins, Phthalocyanines, Photosensitizers, Silica Nanoparticles, PDT, Cancer.
Current Pharmaceutical Design
Title:Targeting Cancer Cells with Photoactive Silica Nanoparticles
Volume: 22 Issue: 39
Author(s): Wioleta Borzęcka, Tito Trindade, Tomás Torres and João Tomé
Affiliation:
Keywords: Porphyrins, Phthalocyanines, Photosensitizers, Silica Nanoparticles, PDT, Cancer.
Abstract: This review highlights recent advances in the preparation of silica nanoparticles (SNPs) functionalized with porphyrins and phthalocyanines for application in cancer photodiagnostic and photodynamic therapy (PDT). The use of photosensitizer-SNP formulations has emerged recently as a new nanomedicine for cancer research owing to their unique physicochemical properties, which make them useful for photo-biomedical applications. In order to study their photobiological properties, diverse chemical strategies involving covalent and non-covalent bonding have been used to load photosensitizers in/on SNPs.
Export Options
About this article
Cite this article as:
Borzęcka Wioleta, Trindade Tito, Torres Tomás and Tomé João, Targeting Cancer Cells with Photoactive Silica Nanoparticles, Current Pharmaceutical Design 2016; 22 (39) . https://dx.doi.org/10.2174/1381612822666160614083804
DOI https://dx.doi.org/10.2174/1381612822666160614083804 |
Print ISSN 1381-6128 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4286 |
Call for Papers in Thematic Issues
Advances in the Molecular Pathogenesis of Inflammatory Bowel Disease.
This thematic issue will emphasize the recent breakthroughs in the mechanisms of Inflammatory bowel disease (IBD) pathogenesis and devotes some understanding of both Crohn’s and ulcerative colitis. It is expected to include studies about cellular and genetic aspects, which help to precipitate the disease, and the immune system-gut microbiome relations ...read more
Blood-based biomarkers in large-scale screening for neurodegenerative diseases
Disease biomarkers are necessary tools that can be employ in several clinical context of use (COU), ranging from the (early) diagnosis, prognosis, prediction, to monitor of disease state and/or drug efficacy. Regarding neurodegenerative diseases, in particular Alzheimer’s disease (AD), a battery of well-validated biomarkers are available, such as cerebrospinal fluid ...read more
Current Pharmaceutical challenges in the treatment and diagnosis of neurological dysfunctions
Neurological dysfunctions (MND, ALS, MS, PD, AD, HD, ALS, Autism, OCD etc..) present significant challenges in both diagnosis and treatment, often necessitating innovative approaches and therapeutic interventions. This thematic issue aims to explore the current pharmaceutical landscape surrounding neurological disorders, shedding light on the challenges faced by researchers, clinicians, and ...read more
Diabetes mellitus: advances in diagnosis and treatment driving by precision medicine
Diabetes mellitus (DM) is a chronic degenerative metabolic disease with ever increasing prevalence worldwide which is now an epidemic disease affecting 500 million people worldwide. Insufficient insulin secretion from pancreatic β cells unable to maintain blood glucose homeostasis is the main feature of this disease. Multifactorial and complex nature of ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Role of Platelet Signaling in Thrombus Stabilization: Potential Therapeutic Implications
Current Signal Transduction Therapy Towards an Experimental and Systems Biology Framework for Cancer Cell Therapeutics
Current Bioinformatics Cardiovascular Diseases and the Nitric Oxide Pathway
Current Vascular Pharmacology Prevalence and Related Factors of Sarcopenia in Community-dwelling Elderly with Long-term Care Insurance
Reviews on Recent Clinical Trials A1 Adenosine Receptor Agonists: Medicinal Chemistry and Therapeutic Potential
Current Pharmaceutical Design Apoptosis Signaling Pathways in Lung Diseases
Medicinal Chemistry Emerging P2Y12 Receptor Antagonists: Role in Coronary Artery Disease
Current Vascular Pharmacology Potential Role of Bone Metabolism Markers in Kidney Transplant Recipients
Current Medicinal Chemistry Biomarkers of Cell Damage Induced by Oxidative Stress in Parkinsons Disease and Related Models
Central Nervous System Agents in Medicinal Chemistry The Valsalva Maneuver and Alzheimers Disease: Is there a link?
Current Alzheimer Research Drugs that Activate Specific Nitric Oxide Sensitive Guanylyl Cyclase Isoforms Independent of Nitric Oxide Release
Current Medicinal Chemistry Aspartic Proteinases in Disease: A Structural Perspective
Current Drug Targets Taste and Hypertension in Humans: Targeting Cardiovascular Disease
Current Pharmaceutical Design Clinical Presentations and Diagnosis of Brucellosis
Recent Patents on Anti-Infective Drug Discovery Inflammatory Biomarkers, Depressive Symptoms and Falls Among the elderly in Panama
Current Aging Science Nutritional and therapeutic approaches to modulate NADPH oxidase-derived ROS signaling in platelets.
Current Pharmaceutical Design Dietary Interventions for Atopic Disorders
Current Pharmaceutical Design Immunosuppressive Treatments in Acute Myocardial Infarction and Stroke
Current Pharmaceutical Biotechnology The Lung Disease of Rheumatoid Arthritis
Current Respiratory Medicine Reviews Myelin Sheaths and Autoimmune Response Induced by Myelin Proteins and Alphaviruses. I. Physicochemical Background
Current Medicinal Chemistry