摘要
完全根除慢性粒细胞白血病在这个高度选择性和强效BCR-ABL络氨酸激酶抑制剂（TKIs）的时代仍具有挑战性。基于TKI治疗CML的难题是TKI不能有效的靶向CML干细胞。已经有几个通路诱导TKI在静态CML干细胞中的不敏感性。本文描述了BCR-ABL/HAUSP/PTEN基因网络，这些信号传导介质能够调节肿瘤抑制基因PTEN的功能。为研究CML干细胞根除，我们也标明了PTEN功能的病理学方法。
关键词: 人第10号染色体缺失的磷酸酶及张力蛋白同源基因，体内外能对p53去泛素的蛋白，BCR-ABL激酶基因，慢性髓细胞样白血病
图形摘要
Call for Papers in Thematic Issues
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Eyesight is one of the most critical senses, accounting for over 80% of our perceptions. Our quality of life might be significantly affected by eye disease, including glaucoma, diabetic retinopathy, dry eye, etc. Although the development of microinvasive ocular surgery reduces surgical complications and improves overall outcomes, medication therapy is ...read more
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