摘要
类风湿性关节炎的特点是关节内的慢性炎症。最近对于炎症理解加深的发展，导致了纳米医学和类风湿关节炎的诊断治疗中的应用的兴趣的增加。 纳米药物的能力，如纳米粒子、渗入和/或保留发炎的关节后静脉和/或关节内给药已被证明在改善类风湿性关节炎治疗的同时对减少患者全身暴露于有潜在毒性的抗关节炎药物是有利的。本文旨在说明类风湿关节炎诊断和治疗医学中的主要应用。
关键词: 抗关节炎药物；慢性炎症；通过渗漏血管外渗；发炎的关节；纳米粒子；单克隆抗体；siRNA。
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Advances in Medicinal Chemistry: From Cancer to Chronic Diseases.
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Cellular and Molecular Mechanisms of Non-Infectious Inflammatory Diseases: Focus on Clinical Implications
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Chalcogen-modified nucleic acid analogues
Chalcogen-modified nucleosides, nucleotides and oligonucleotides have been of great interest to scientific research for many years. The replacement of oxygen in the nucleobase, sugar or phosphate backbone by chalcogen atoms (sulfur, selenium, tellurium) gives these biomolecules unique properties resulting from their altered physical and chemical properties. The continuing interest in ...read more
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