摘要
美西律是一类IB级口服抗心律失常药。虽然最初是针对室性心律失常的治疗，但它已被证明对慢性疼痛性糖尿病神经病变，神经性疼痛，骨骼肌离子通道也有治疗作用，最近发现其对肌萎缩侧索硬化症也有作用。本综述详细报道了外消旋体和手性的美西律在近几十年发展起来的不同合成路线，以及手性分离方法和对映体过量测定的分析研究。最后，本文也提到了一些文献中报道的美西律类似物，大部分还介绍了对应的药理研究。
关键词: Antiarrhythmic agents
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