摘要
表皮生长因子受体（EGFR）是抗肿瘤治疗中最重要的靶点之一。到目前为止，大量的第一代和第二代针对表皮生长因子受体的酪氨酸激酶抑制剂（TKIs）已上市或进入临床研究阶段。然而，TKI耐药突变的发生导致了这些抑制剂的药效的降低。为了克服耐药突变和减少副作用，许多第三代EGFR抑制剂都从具有良好的抗EGFR突变的效力方面去研发而不同于野生型的EGFR。本文概述了第三代EGFR抑制剂的发展现状，主要关注了生物学特性、临床状态和构效关系。
关键词: Anticancer
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Advances in Medicinal Chemistry: From Cancer to Chronic Diseases.
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Cellular and Molecular Mechanisms of Non-Infectious Inflammatory Diseases: Focus on Clinical Implications
The Special Issue covers the results of the studies on cellular and molecular mechanisms of non-infectious inflammatory diseases, in particular, autoimmune rheumatic diseases, atherosclerotic cardiovascular disease and other age-related disorders such as type II diabetes, cancer, neurodegenerative disorders, etc. Review and research articles as well as methodology papers that summarize ...read more
Chalcogen-modified nucleic acid analogues
Chalcogen-modified nucleosides, nucleotides and oligonucleotides have been of great interest to scientific research for many years. The replacement of oxygen in the nucleobase, sugar or phosphate backbone by chalcogen atoms (sulfur, selenium, tellurium) gives these biomolecules unique properties resulting from their altered physical and chemical properties. The continuing interest in ...read more
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