摘要
背景：卵巢癌是导致妇科恶性肿瘤的主要死亡原因。 晚期诊断和高转移倾向和耐药性往往导致复发和不良结局。 抗血管生成被认为是复发性卵巢癌的有希望的治疗策略。 抗VEGF体，贝伐单抗，是具有活性和可耐受毒性的血管生成抑制剂。目的：阐明贝伐珠单抗治疗复发性卵巢癌的疗效和副作用。 方法：审查已发表的临床试验结果。 结果：最近的II期研究表明，贝伐单抗单一疗法或与常规或其他抗血管生成化疗试剂组合可能对复发（铂敏感和抗药性）卵巢癌有效。 另外，两个III期随机试验得出了类似的结论，即在铂敏感或抵抗性卵巢癌中，将贝伐珠单抗加入化疗可以改善无进展生存期。 尽管贝伐珠单抗在复发性卵巢癌患者中被普遍认可为良好耐受的药物，但肿瘤学家已经意识到与胃肠穿孔有关的重大风险。 结论：贝伐单抗单独使用或与其他化学疗法组合使用对治疗复发性卵巢癌有效和耐受。
关键词: 贝伐单抗，化疗，疗效，卵巢癌，复发，安全性，化疗。
图形摘要
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