摘要
Rho相关蛋白激酶（ROCK）是一个丝氨酸-‘苏氨酸激酶’最初被鉴定为一种关键的肌动蛋白细胞骨架的调节器. 近期的研究已经对ROCK作为一种神经多种信号通路的关键成分定义了新的功能。此外，ROCK的抑制造成了多种生物反应如副产物突起的增加、轴突增加、促生存Akt的激活。因此，它已经吸引了研究人员的兴趣并且认为ROCK是一种对神经退行性疾病紊乱包括阿尔兹海默症、帕金斯疾病、亨廷顿氏病、多发性硬化症、肌肉萎缩性侧索硬化症有潜力的治疗靶点。然而，RCOK2两种高度相似的同工型，ROCK1和ROCK2。越来越多的证据表明，ROCK1和ROCK2可能参与不同的细胞功能的中枢神经系统（CNS）和神经退行性过程。本文综述了近期更新的关于ROCK同工型在CNS特殊的功能，以及ROCK抑制剂在神经退行性疾病的临床前研究。
关键词: 轴突再生、中枢神经系统、法舒地尔、亚型、LIMK、神经减退性疾病、挑战
图形摘要
Call for Papers in Thematic Issues
Drug-Targeted Approach with Polymer Nanocomposites for Improved Therapeutics
Polymer nanocomposites have been recognized as an advanced and cutting-edge technique in drug targeting administration. These materials combine the unique features of nanoparticles with the adaptability of polymers to produce highly personalized drug administration devices. Integrating nanoparticles containing pharmaceuticals into a polymer matrix enables researchers to regulate the rates at ...read more
New drug therapy for eye diseases
Eyesight is one of the most critical senses, accounting for over 80% of our perceptions. Our quality of life might be significantly affected by eye disease, including glaucoma, diabetic retinopathy, dry eye, etc. Although the development of microinvasive ocular surgery reduces surgical complications and improves overall outcomes, medication therapy is ...read more
Therapeutic Chemical and RNA Design with Artificial Intelligence
Computer-Aided Drug Design (CADD) has emerged as a fundamental component of modern drug discovery. Molecular docking facilitates virtual screening on a large scale through structural simulations. However, traditional CADD approaches face significant limitations, as they can only screen known compounds from existing libraries. PubChem, as the most widely used chemical ...read more
Related Journals
Anti-Cancer Agents in Medicinal Chemistry
Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry
Current Bioactive Compounds
Current Cancer Drug Targets
Combinatorial Chemistry & High Throughput Screening
Current Cancer Therapy Reviews
Current Diabetes Reviews
Current Drug Safety
Current Drug Therapy
Current Drug Delivery
Related Books
Anthocyanins: Pharmacology and Nutraceutical Importance
Computer-Aided Drug Discovery Methods: A Brief Introduction
The Roles and Responsibilities of Clinical Pharmacists in Hospital Settings
Bioactive Compounds from Medicinal Plants for Cancer Therapy and Chemoprevention
Drug Addiction Mechanisms in the Brain
Software and Programming Tools in Pharmaceutical Research
Objective Pharmaceutics: A Comprehensive Compilation of Questions and Answers for Pharmaceutics Exam Prep
Medicinal Chemistry of Drugs Affecting Cardiovascular and Endocrine Systems
Medicinal Plants, Phytomedicines and Traditional Herbal Remedies for Drug Discovery and Development against COVID-19
Advanced Pharmacy
126
14
