Activated MR Contrast Agents

Mark   P.   Lowe

doi:10.2174/1389201043376562

Abstract

The relative non-specificity of the first generation MR contrast agents has meant that a new approach to their design is required. This review focuses on a new class of more specific or functional agents. These are the so-called “activated”, “smart” or “responsive” contrast agents. The relaxivity of an activated contrast agent is responsive to (or can be modulated by) a particular in vivo stimulus such as a change in biological environment or activity. More specifically, a “switching on” of contrast in response to an event such as a change in physiological pH, metal ion concentration, enzyme activity or partial pressure of oxygen is sought. The current generation of activated MR contrast agents is discussed herein.

Keywords: oxygen, MR Contrast Agents

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Current Pharmaceutical Biotechnology

Title: Activated MR Contrast Agents

Volume: 5 Issue: 6

Author(s): Mark P. Lowe

Affiliation:

Keywords: oxygen, MR Contrast Agents

Abstract: The relative non-specificity of the first generation MR contrast agents has meant that a new approach to their design is required. This review focuses on a new class of more specific or functional agents. These are the so-called “activated”, “smart” or “responsive” contrast agents. The relaxivity of an activated contrast agent is responsive to (or can be modulated by) a particular in vivo stimulus such as a change in biological environment or activity. More specifically, a “switching on” of contrast in response to an event such as a change in physiological pH, metal ion concentration, enzyme activity or partial pressure of oxygen is sought. The current generation of activated MR contrast agents is discussed herein.

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Cite this article as:

Lowe P. Mark, Activated MR Contrast Agents, Current Pharmaceutical Biotechnology 2004; 5 (6) . https://dx.doi.org/10.2174/1389201043376562

DOI https://dx.doi.org/10.2174/1389201043376562	Print ISSN 1389-2010
Publisher Name Bentham Science Publisher	Online ISSN 1873-4316

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