摘要
在最近的几十年中，人们对整合素受体在癌症生物学特别是在前列腺肿瘤的发展中的应用越来越感兴趣。有报道称整合素能调控多种机制，如细胞的存活、增殖、分化和迁移。本文报道了整合素信号机制在转移性前列腺肿瘤发展、肿瘤生长原发灶和转移灶之间的信号联系、肿瘤细胞和组织微环境之间的相互作用和上皮间质转化（EMT）中的作用。最后，本文讨论了以整合素为基础的化疗药物在临床上的作用，并对以整合素为靶点作为癌症药物提出了深刻的见解。
关键词: 拮抗剂治疗，整合素，前列腺癌。
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