结肠直肠癌纳米粒子靶向给药和磁共振成像的研究现状及展望

Title:Nanoparticles for Colorectal Cancer Targeted Drug Delivery and MR Imaging: Current Situation and Perspectives

Volume: 16 Issue: 6

Author(s): Zhi Dong, Min-Yi Cui, Zhenpeng Peng, Yin Li, Xiaoling Wang, Zhuangnian Fang, Mengjie Jiang, Ling Xu, Yanji Luo, Zi-Ping Li and Shi-Ting Feng

Affiliation:

关键词: 结肠直肠癌靶向；给药；磁共振成像；主动控制

摘要: The application of nanoparticles (NPs) offers new prospects for the early detection and effective therapy of colorectal cancer (CRC). Various NPs have been designed and explored as diagnostic and/or therapeutic drug delivery vehicles. To achieve selective treatment and to reduce toxicity, these nanoparticles are usually endowed with targeting abilities. Passive targeting is based on the extravasation and enhanced permeability and retention effect of tumors, while active targeting always involves binding to specific ligands that are recognizable by CRC tissues, such as vascular endothelial growth factor, folate, monoclonal antibodies (mAbs), aptamers, and membrane penetrating peptides. In addition, contrast agents, such as gadolinium complexes and iron oxide particles, can be introduced into the delivery system to enable MR imaging and lesion detection. Furthermore, smart carriers have been gradually applied to the delivery system. These carriers are designed to respond to certain changes in the bio-environment and release encapsulated contents on demand, thus achieving effective drug concentrations at tumor sites. This review focuses on recent advances of NP technology for the targeted diagnosis and treatment of CRC and aims to unveil the emerging possibilities of using nanocarriers to enhance therapeutic applications.

Cite this article as:

Zhi Dong, Min-Yi Cui, Zhenpeng Peng, Yin Li, Xiaoling Wang, Zhuangnian Fang, Mengjie Jiang, Ling Xu, Yanji Luo, Zi-Ping Li and Shi-Ting Feng , Nanoparticles for Colorectal Cancer Targeted Drug Delivery and MR Imaging: Current Situation and Perspectives, Current Cancer Drug Targets 2016; 16 (6) . https://dx.doi.org/10.2174/1568009616666151130214442