博莱霉素的靶向给药：一个广泛的抗癌剂综述

Title:Targeted Delivery of Bleomycin: A Comprehensive Anticancer Review

Volume: 16 Issue: 6

Author(s): Zhiqiang Yu, Bo Yan, Liqian Gao, Chenbo Dong, Jian Zhong, Mathew D'Ortenzio, Brandon Nguyen, Su Seong Lee, Xianglong Hu and Feng Liang

Affiliation:

关键词: 博莱霉素；电化学；脂质体；微球；纳米粒子；光化学内化；靶向给药；超声

摘要: Despite being one of the most effective broad-spectrum chemotherapeutic agents in the treatment of cancers, the clinical applications of bleomycins (BLMs) have been limited due to their poor drug delivery abilities, and the side effect of causing lung fibrosis. With the increased therapeutics and the reduction of side effects, research and development of targeted drug delivery systems (TDDS) with BLMs have become essential for the expansive clinical usage of BLM-based therapeutics. This review summarizes the recent developments of various TDDS for BLMs, including techniques such as photochemical internalization, ultrasound, and micelle, liposome, and nanoparticle formation. The advantages and disadvantages for each delivery approach are outlined, along with the specific challenges associated with each delivery system.

Cite this article as:

Zhiqiang Yu, Bo Yan, Liqian Gao, Chenbo Dong, Jian Zhong, Mathew D'Ortenzio, Brandon Nguyen, Su Seong Lee, Xianglong Hu and Feng Liang , Targeted Delivery of Bleomycin: A Comprehensive Anticancer Review, Current Cancer Drug Targets 2016; 16 (6) . https://dx.doi.org/10.2174/1568009616666151130213910