摘要
在过去的二十年中,来自植物的生物活性的化合物已被报道作为新的治疗剂用于预防和/或减轻不同的人类疾病,例如癌症,炎症,心血管疾病和神经变性疾病。橙皮苷具备多种健康促进作用被认为柑橘(C)最常见和生物活性成分之一。科学文献的大量报道,橙皮苷具有在体外和体内抗癌活性。此外,也有大量科学证据关于橙皮苷和其糖苷配基,橙皮素抗癌活性的分子机制。然而,在这种情况下,综合评价关于分子机制橙皮苷的抗癌作用文献是稀少的。因此,在此工作中,我们将呈现现有文献报道的有关橙皮苷和其糖苷配基,橙皮素的抗癌作用的分子机制。
关键词: 糖苷配基,抗癌,柑橘属,黄酮,橙皮素,橘皮素
Current Medicinal Chemistry
Title:The Role of Hesperidin in Cell Signal Transduction Pathway for the Prevention or Treatment of Cancer
Volume: 22 Issue: 30
Author(s): A. Ahmadi, A. Shadboorestan, S.F. Nabavi, W.N. Setzer and S.M. Nabavi
Affiliation:
关键词: 糖苷配基,抗癌,柑橘属,黄酮,橙皮素,橘皮素
摘要: During past two decades, plant-derived bioactive compounds have been reported as novel therapeutic agents for prevention and/or mitigation of different human diseases such as cancer, inflammation, cardiovascular and neurodegenerative diseases. Hesperidin is known as one of the most common and bioactive constituents of Citrus (C) species which possesses multiple health-promotion effects. A plethora of scientific literature reported that hesperidin possesses in-vitro and in-vivo anticancer activities. In addition, there are numerous scientific evidences regarding the molecular mechanisms of anticancer activities of hesperidin and its aglycone, hesperetin. However, in this case, the number of comprehensive reviews on molecular mechanisms underlying the anticancer effects of hesperidin is sparse. Therefore, in this work we present a critical review of the available literature regarding the molecular mechanisms of the anticancer effects of hesperidin and its aglycone, hesperetin.
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A. Ahmadi, A. Shadboorestan, S.F. Nabavi, W.N. Setzer and S.M. Nabavi , The Role of Hesperidin in Cell Signal Transduction Pathway for the Prevention or Treatment of Cancer, Current Medicinal Chemistry 2015; 22 (30) . https://dx.doi.org/10.2174/092986732230151019103810
DOI https://dx.doi.org/10.2174/092986732230151019103810 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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