摘要
近数十年,珊瑚衍生微生物群成为了许多海洋生态学研究学者关注的焦点。重要地是,在过去的五年,关于这些多样微生物(包括真菌和细菌)活性化合物的研究迅速增加。这揭示了这些微生物的生态作用,预防海洋生态系统的污染、抑制其致病菌和制止捕食者。此外,从这些微生物得到的结构多样和具有药理活性的化合物,也得到了广泛研究;不仅导致了解了他们在生态系统的作用,也包括他们在人类健康应用方面的潜在价值。本文总结了在过去24年中发现的258种海洋天然产物,其中包括聚酮类、萜类、杂萜类、 生物碱、多肽类、莽草酸和脂质化合物。引用了146篇参考文献。
关键词: 生物碱,防污,抗微生物,抗肿瘤,多种多样性,珊瑚衍生微生物,聚酮类化合物
Current Medicinal Chemistry
Title:Biological and Chemical Diversity of Coral-Derived Microorganisms
Volume: 22 Issue: 32
Author(s): Xue-Mei Hou, Ru-Fang Xu, Yu-Cheng Gu, Chang-Yun Wang and Chang-Lun Shao
Affiliation:
关键词: 生物碱,防污,抗微生物,抗肿瘤,多种多样性,珊瑚衍生微生物,聚酮类化合物
摘要: Coral-derived microorganisms have been a major focus of many research efforts on marine ecology in recent decades. Importantly, research on bioactive compounds from these diverse microorganisms, which include fungi and bacteria, has experienced an explosive growth during the past five years. This has unveiled the ecological roles of these microorganisms, which prevent antifouling, inhibit pathogenic bacteria, and deter predators in ocean ecosystems. Moreover, the structural diversity and pharmacological activity of the compounds produced by these microorganisms have also been studied extensively, leading not only to an understanding their roles within ecosystems, but also the potential value of their use in human health. In this review, 258 marine natural products, including polyketides, terpenoids, meroterpenoids, alkaloids, peptides, shikimates and lipids, all discovered in the past 24 years, are presented. 146 references are cited.
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Cite this article as:
Xue-Mei Hou, Ru-Fang Xu, Yu-Cheng Gu, Chang-Yun Wang and Chang-Lun Shao , Biological and Chemical Diversity of Coral-Derived Microorganisms, Current Medicinal Chemistry 2015; 22 (32) . https://dx.doi.org/10.2174/0929867322666151006093755
DOI https://dx.doi.org/10.2174/0929867322666151006093755 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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