摘要
Hippo信号通路对于调节组织稳态、器官大小和肿瘤发生中是至关重要的。YAP和TAZ，Hippo信号通路的两个主要效应蛋白，是转录共激活因子并主要通过与TEAD家族转录因子的相互作用促进靶基因的表达。作为癌基因蛋白，YAP和TAZ在各种癌症样本中被频繁激活或高表达。此外，它们的活动被认为与几种广泛使用的抗癌药物的耐药有关，且YAP活化有助于肿瘤的复发。因此，Hippo通路，特别是YAP/TAZ-TEAD相互作用，是抗癌治疗的一个引人注目的靶点。本文将讨论抑制Yap / TAZ活性的可能途径，并综述目前可用的靶向Hippo通路的小分子。
关键词: Hippo，TAZ， TEAD，Verteporfin，VGLL4， YAP。
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