摘要
细胞外囊泡(EVs)是来自胞内体通路或细胞质膜不同类型的膜囊泡。这些囊泡被用作细胞间沟通的“载体”,并负责在不同细胞之间生物(脂类、蛋白质、核糖核酸RNA、脱氧核糖核酸DNA)的转移。尽管我们对EV的生物学知识的了解不够,试图以EVs为天然的传递工具作为治疗目的,在不同的情况一定程度上是成功的。在这篇综述中,我们强调EVs的独特的潜在性,并讨论了之前的范例和未来的设想。
关键词: 癌症,传递,细胞外囊泡,治疗学
Current Cancer Drug Targets
Title:Extracellular Vesicles as Novel Delivery Tools for Cancer Treatment
Volume: 16 Issue: 1
Author(s): Erdogan Pekcan Erkan and Okay Saydam
Affiliation:
关键词: 癌症,传递,细胞外囊泡,治疗学
摘要: Extracellular vesicles (EVs) are different types of membrane-derived vesicles that originate from the endosomal pathway or the plasma membrane. These vesicles are used as "carriers" in intercellular communication, and are responsible for the transfer of biological cargo (lipids, proteins, RNA species, and DNA) between different cells. Despite the shortcomings in our knowledge of EV biology, attempts to employ EVs as natural delivery tools for therapeutic purposes have been partly successful in different settings. In this review, we highlight this unique potential of EVs, and discuss previous examples and future scenarios.
Export Options
About this article
Cite this article as:
Erdogan Pekcan Erkan and Okay Saydam , Extracellular Vesicles as Novel Delivery Tools for Cancer Treatment, Current Cancer Drug Targets 2016; 16 (1) . https://dx.doi.org/10.2174/1568009615666150923115439
DOI https://dx.doi.org/10.2174/1568009615666150923115439 |
Print ISSN 1568-0096 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-5576 |
Call for Papers in Thematic Issues
Innovative Cancer Drug Targets: A New Horizon in Oncology
Cancer remains one of the most challenging diseases, with its complexity and adaptability necessitating continuous research efforts into more effective and targeted therapeutic approaches. Recent years have witnessed significant progress in understanding the molecular and genetic basis of cancer, leading to the identification of novel drug targets. These include, but ...read more
Role of Immune and Genotoxic Response Biomarkers in Tumor Microenvironment in Cancer Diagnosis and Treatment
Biological biomarkers have been used in medical research as an indicator of a normal or abnormal process inside the body, or of a disease. Nowadays, various researchers are in process of exploring and investigating the biological markers for the early assessment of cancer. DNA Damage response (DDR) pathways and immune ...read more
The Impact of Cancer Neuroscience on Novel Brain Cancer Treatment
Brain cancer remains one of the most challenging malignancies due to its complexity and resistance to conventional therapies. Recent advancements in cancer neuroscience have transformed our understanding of the brain's tumor microenvironment, offering promising insights into novel treatments. By studying the intricate interactions between cancer cells and the nervous system, ...read more
Unraveling the Tumor Microenvironment and Potential Therapeutic Targets: Insights from Single-Cell Sequencing and Spatial Transcriptomics
This special issue will focus on unraveling the complexities of the tumor microenvironment (TME) and identifying key biomarkers for potential therapeutic targets using advanced multi-omics techniques, such as single-cell sequencing and spatial transcriptomics. We seek original research and comprehensive reviews that investigate the heterogeneity and dynamics of the TME, emphasizing ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
(Bio)chemical Labelling Tools for Studying Absorption & Metabolism of Dietary Phenols - An Overview
Current Organic Chemistry Structure and Regulation of the Drug-Metabolizing Enzymes Arylamine N-acetyltransferases
Current Medicinal Chemistry Prostaglandin E Synthase: A Novel Drug Target for Inflammation and Cancer
Current Pharmaceutical Design Automatic Kidney Stone Composition Analysis Method Based on Dual-energy CT
Current Medical Imaging Recent Advances in Oncogenic Roles of the TRPM7 Chanzyme
Current Medicinal Chemistry Current & Future Therapies of Erectile Dysfunction in Neurological Disorders
Recent Patents on CNS Drug Discovery (Discontinued) Antiviral Compounds Based on Natural Astragalus polysaccharides (APS): Research and Foresight in the Strategies for Combating SARS-CoV-2 (COVID-19)
Mini-Reviews in Medicinal Chemistry The Renin-angiotensin System as a Target of Novel Anticancer Therapy
Current Pharmaceutical Design Identification of Novel Anti-inflammatory Agents from Ayurvedic Medicine for Prevention of Chronic Diseases: “Reverse Pharmacology” and “Bedside to Bench” Approach
Current Drug Targets Identification of Essential Genes and Drug Discovery in Bladder Cancer and Inflammatory Bowel Disease <i>via</i> Text Mining and Bioinformatics Analysis
Current Computer-Aided Drug Design Herbal Nanoparticles: A New Perspective of Drug Delivery System- A Review
Nanoscience & Nanotechnology-Asia Recents Patents for Isolating, Delivering and Tracking Adult Stem Cells in Regenerative Medicine
Recent Patents on Drug Delivery & Formulation Radiosynthesis of N.C.A. Sodium [18F]Fluoroacetate and Radiopharmacological Characterization in Rats and Tumor-Xenografted Mice
Current Radiopharmaceuticals Organosulfur Compounds in Cancer Chemoprevention
Mini-Reviews in Medicinal Chemistry In Vivo Cellular Imaging for Translational Medical Research
Current Medical Imaging TRPM8: From Cold to Cancer, Peppermint to Pain
Current Pharmaceutical Biotechnology Neuro-Transmitters in the Central Nervous System & their Implication in Learning and Memory Processes
Current Medicinal Chemistry From Multiple PAR1 Receptor/Protein Interactions to their Multiple Therapeutic Implications
Current Topics in Medicinal Chemistry Aging and Inflammation: Etiological Culprits of Cancer
Current Aging Science The Therapeutic Potential of ADAM15
Current Pharmaceutical Design