Abstract
The aldol reactions catalyzed by aldolases are an important tool in the synthesis of different products or building blocks. However, despite its advantages, aldolases, as enzymes, have some troubles as their low activity against synthetic substrates or the low stability, doing difficult their application. There are different tools to improve the properties of this enzyme such as directed mutagenesis, directed evolution or the immobilization methods. The immobilization not only is able to improve the properties of the enzymes but also permits the reuse of the catalysts. This review is focused on the immobilization of different aldolases using different methodologies.
Keywords: Aldolase, enzyme immobilization, solid supports.
Current Organic Chemistry
Title:Immobilization of Aldolase for C-C Bond Formation
Volume: 20 Issue: 11
Author(s): Caio C. Aragon, Jose M. Palomo, Marco Filice and Cesar Mateo
Affiliation:
Keywords: Aldolase, enzyme immobilization, solid supports.
Abstract: The aldol reactions catalyzed by aldolases are an important tool in the synthesis of different products or building blocks. However, despite its advantages, aldolases, as enzymes, have some troubles as their low activity against synthetic substrates or the low stability, doing difficult their application. There are different tools to improve the properties of this enzyme such as directed mutagenesis, directed evolution or the immobilization methods. The immobilization not only is able to improve the properties of the enzymes but also permits the reuse of the catalysts. This review is focused on the immobilization of different aldolases using different methodologies.
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Cite this article as:
C. Aragon Caio, M. Palomo Jose, Filice Marco and Mateo Cesar, Immobilization of Aldolase for C-C Bond Formation, Current Organic Chemistry 2016; 20 (11) . https://dx.doi.org/10.2174/1385272819666150831202640
DOI https://dx.doi.org/10.2174/1385272819666150831202640 |
Print ISSN 1385-2728 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5348 |
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