摘要
多年来，Polo样激酶1（Plk1）作为治疗靶点已经获得巨大的效益。Plk1是高度保守的丝氨酸/苏氨酸激酶之一，在真核细胞有丝分裂，细胞分裂和DNA损伤反应起着关键作用。本文总结了Plk1在细胞周期的功能、其在治疗儿童癌症方面的作用和作为预后因素的价值。此外，本文介绍了药物抑制的研究进展以及以Plk1为靶点的小分子药物治疗癌症的化疗方法的发展。最后，对PLK1抑制剂的临床试验进行了简要回顾。
关键词: 化疗，抑制剂，小儿肿瘤，PLK1，化疗，抑制剂，小儿肿瘤，PLK1，放疗，治疗。
图形摘要
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