摘要
抗毒蕈碱(AMS)和β3受体激动剂(β3As))联合治疗最近被提议为治疗膀胱过度活动症(OAB)患者可行方法。数据采集:国家生物技术信息中心通过PubMed检索了2007到2014之间的相关文章 ,其搜索主题结合了患者人群、干预、比较、疗效:膀胱过度活动症,抗毒蕈碱,β3受体激动剂,联合治疗,疗效,耐受性和疗效。附加的参考文献来自于全文,摘要发表在的欧洲泌尿协会、美国泌尿学协会和国际尿控协会年度大会上。证据合成:治疗OAB的联合疗法已经进行了动物实验和二期随机临床试验研究。与AMS单药治疗相比,联合治疗能改善平均排尿量、排尿频率和尿急情况。联合治疗组和单药治疗组的不良反应都与与剂量无关。联合治疗组便秘发生率略有增加。结论:联合治疗对治疗OAB安全有效。然而,需要进一步研究其成本效益来评估其治疗OAB患者的决定性作用。
关键词: 抗毒蕈碱,β3受体激动剂,联合治疗,疗效,膀胱过度活动症,安全性。
Current Drug Targets
Title:The Current Indications and the Benefits of Combining a β3-Agonist with an Anticholinergic for the Treatment of OAB
Volume: 16 Issue: 11
Author(s): Cosimo De Nunzio, Fabrizio Presicce, Luisella Pirozzi, Pietro Castellan, Luigi Schips, Luca Cindolo, Riccardo Lombardo and Andrea Tubaro
Affiliation:
关键词: 抗毒蕈碱,β3受体激动剂,联合治疗,疗效,膀胱过度活动症,安全性。
摘要: Combination therapy with anti-muscarinics (AMs) and β3 agonists (β3As) has recently been proposed as a possible treatment for the management of patients with Overactive Bladder (OAB). Evidence acquisition: A National Center for Biotechnology Information PubMed search for relevant articles published between 2007 and 2014 was performed by combining the following Patient population, Intervention, Comparison, Outcome (PICO) terms: overactive bladder, antimuscarinics, β3 agonists, combination therapy, efficacy, tolerability and outcomes. Additional references were obtained from the reference list of full-text manuscripts. Abstracts presented at the annual congresses of the European Association of Urology, American Urology Association and the International Continence Society were included. Evidence Synthesis: The combination therapy, in the management of OAB symptoms, has recently been investigated in animal models and in a phase II randomized clinical trial. Compared with AMs monotherapy, combination treatment improved mean voided volume per micturition, micturition frequency and reduced urgency episodes. No dose related trends in adverse events (AEs) were observed between combination group and monotherapy group. Incidence of constipation was slightly increased in combination therapy group. Conclusions: Combination therapy seems to be an effective and safe treatment in the management of OAB. However, further cost-effectiveness studies are needed to evaluate the definitive role of this approach for the management of patients with OAB.
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Cosimo De Nunzio, Fabrizio Presicce, Luisella Pirozzi, Pietro Castellan, Luigi Schips, Luca Cindolo, Riccardo Lombardo and Andrea Tubaro , The Current Indications and the Benefits of Combining a β3-Agonist with an Anticholinergic for the Treatment of OAB, Current Drug Targets 2015; 16 (11) . https://dx.doi.org/10.2174/1389450116666150806124345
DOI https://dx.doi.org/10.2174/1389450116666150806124345 |
Print ISSN 1389-4501 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-5592 |
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