新兴抗癌化合物：植物和真菌的二次代谢产物氧异戊烯基

Title:A Novel Class of Emerging Anticancer Compounds: Oxyprenylated Secondary Metabolites from Plants and Fungi

Volume: 22 Issue: 30

Author(s): Salvatore Genovese, Serena Fiorito, Francesco Epifano and Vito Alessandro Taddeo

Affiliation:

关键词: 蒽醌类，癌症，查耳酮，肉桂酸，香豆素，二酮哌嗪，氧异戊烯基次级代谢产物

摘要: O-Prenyl secondary metabolites (3,3-dimethylallyl, geranyl-, farnesyl- and related biosynthetic derivatives) represent a class of rarely occurring natural products. In the last two decades such compounds have been found to exert promising and effective pharmacological activities, mainly in terms of anti-cancer properties. To date about 350 oxyprenylated secondary metabolites, the most part of which having a phenylpropanoid or a polyketide core, have been extracted from plants mainly belonging to the Rutaceae, Apiaceae, and Fabaceae families, and from fungi and bacteria. The aim of this comprehensive review is to make a survey of the in so far reported literature citations about O-prenyl secondary metabolites exhibiting in vitro and in vivo anti-cancer properties from phytochemical and pharmacological point of views.

Cite this article as:

Salvatore Genovese, Serena Fiorito, Francesco Epifano and Vito Alessandro Taddeo , A Novel Class of Emerging Anticancer Compounds: Oxyprenylated Secondary Metabolites from Plants and Fungi, Current Medicinal Chemistry 2015; 22 (30) . https://dx.doi.org/10.2174/0929867322666150716114758