摘要
杂环氮氧化物已经成为一类具有抗肿瘤、抗菌、降血压、抗寄生虫、抗HIV、抗炎、除草、神经保护、强化认知等活性的化合物。最近，以氮氧为母核的化合物已被成功地应用在一些药物研发项目中。本文以主流药物化学为支点，主要综述了杂环氮氧化物类药物的发现，氮氧特别的作用机制，药物与受体的相互作用以及这些化合物的合成路径。这是关于该主题的第一篇综述，涵盖了自上世纪50年代以来的相关研究成果，预计将会激发更广泛的以杂环氮氧为母核新兴药的合理设计。
关键词: 杂环氮氧化物，一氧化氮模拟物，生物电子等排体，低氧血症，Xa因子抑制剂，凝血-级联型直接凝血酶抑制剂，抗南美洲锥虫病药，抗疟药
Call for Papers in Thematic Issues
Advances in Medicinal Chemistry: From Cancer to Chronic Diseases.
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Approaches to the Treatment of Chronic Inflammation
Chronic inflammation is a hallmark of numerous diseases, significantly impacting global health. Although chronic inflammation is a hot topic, not much has been written about approaches to its treatment. This thematic issue aims to showcase the latest advancements in chronic inflammation treatment and foster discussion on future directions in this ...read more
Cellular and Molecular Mechanisms of Non-Infectious Inflammatory Diseases: Focus on Clinical Implications
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Chalcogen-modified nucleic acid analogues
Chalcogen-modified nucleosides, nucleotides and oligonucleotides have been of great interest to scientific research for many years. The replacement of oxygen in the nucleobase, sugar or phosphate backbone by chalcogen atoms (sulfur, selenium, tellurium) gives these biomolecules unique properties resulting from their altered physical and chemical properties. The continuing interest in ...read more
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