Acute and Chronic Treatments with Quetiapine Increase Mitochondrial Respiratory Chain Complex Activity in the Rat Brain

Title:Acute and Chronic Treatments with Quetiapine Increase Mitochondrial Respiratory Chain Complex Activity in the Rat Brain

Volume: 12 Issue: 3

Author(s): Zuleide M. Ignacio, Gislaine Z. Reus, Helena M. Abelaira, Stephanie E. Titus, Anelise S. Carlessi, Jaine R. da Luz, Beatriz I. Matias, Livia Bruchchen, Milena Carvalho-Silva, Lara M. Gomes, Joyce Rebelo, Emilio L. Streck and Joao Quevedo

Affiliation:

Keywords: Quetiapine; antidepressant, energy metabolism, creatine kinase, mitochondrial respiratory chain, depression.

Abstract: Several studies have found that the molecular mechanisms of mitochondrial energy metabolism are impaired in major depressive disorder (MDD). Classic antidepressants and atypical antipsychotics can alter the function of enzymes involved in adenosine triphosphate (ATP) metabolism. Quetiapine is an atypical antipsychotic that, in addition to having a therapeutic benefit in treating MDD, appears to exert antioxidant and neuroprotective effects. Therefore, we aimed to evaluate the acute and chronic effects of quetiapine on the activity of enzyme complexes I to IV of the mitochondrial respiratory chain and creatine kinase (CK) in brain regions involved with MDD. After a single dose or serial injections over 14 days of quetiapine (20, 40, and 80 mg) were administered, isolates from the pre- frontal cortex, hippocampus, amygdala and nucleus accumbens were analyzed for enzyme activity levels. The enzyme activity varied according to the dose, brain region, and acute or chronic dosing protocols. In general, complexes I-III activity was increased, especially after acute administration. Acute administration also increased the activity of complex IV and CK in the amygdala while complex I was inhibited in the prefrontal cortex and nucleus accumbens. These results suggest that quetiapine produces an increase in respiratory chain complex activity, which may be underlying its efficacy against psychiatric disorders and neuronal damage.

Cite this article as:

Ignacio M. Zuleide, Reus Z. Gislaine, Abelaira M. Helena, Titus E. Stephanie, Carlessi S. Anelise, da Luz R. Jaine, Matias I. Beatriz, Bruchchen Livia, Carvalho-Silva Milena, Gomes M. Lara, Rebelo Joyce, Streck L. Emilio and Quevedo Joao, Acute and Chronic Treatments with Quetiapine Increase Mitochondrial Respiratory Chain Complex Activity in the Rat Brain, Current Neurovascular Research 2015; 12 (3) . https://dx.doi.org/10.2174/1567202612666150603140912