预测阿尔茨海默氏症的轻度认知障碍中听觉言语学习测试优于Rey-Osterrieth复杂图形测验

Title:Auditory Verbal Learning Test is Superior to Rey-Osterrieth Complex Figure Memory for Predicting Mild Cognitive Impairment to Alzheimer’s Disease

Volume: 12 Issue: 6

Author(s): Qianhua Zhao, Qihao Guo, Xiaoniu Liang, Meirong Chen, Yan Zhou, Ding Ding and Zhen Hong

Affiliation:

关键词: 阿茨海默氏症，听觉言语学习测试，轻度认知功能障碍，操作标准，Rey-Osterrieth复杂图形测验，主观认知减退。

摘要: Objective: To carry out meaningful comparisons on results of different research studies on mild cognitive impairment (MCI), it is critical to select an appropriate objective memory test to examine memory deficit. We aim to refine the operational criteria of amnestic MCI (aMCI) on neuropsychological tests that optimally balance the sensitivity and specificity. Methods: We focused on 206 non-demented subjects from memory clinic. We then classified each individual as having MCI or subjective cognitive decline (SCD) according to different neuropsychological criteria. By following them longitudinally, clinical outcomes were compared to evaluate the stability of MCI diagnoses and prediction of progression. Results: The delayed recall of auditory verbal learning test (AVLT_DR) identified 116 subjects as MCI, resulted in the conversion rate as 44% over the roughly 30-month time interval, missed 7.8% incipient Alzheimer’s disease (AD) patients in SCD group who eventually converted to dementia. The delayed recall of complex figure test (CFT_DR) identified fewer MCI patients (n=95) and misdiagnosed more preclinical AD patients (15.3%), in comparison with AVLT criterion. Criterion requiring deficits in both tests produced higher conversion rate (54.3%), but resulted in higher misdiagnosis rate (14.7%) simultaneously. The AVLT criterion had the largest area under the curve (0.7248, p<0.05). Conclusion: AVLT is superior to CFT in the stability of diagnoses and prediction of progression. In the clinical setting, the “one test” criterion AVLT has similar sensitivity to both-deficits methods, and is optimal in balancing sensitivity and specificity.

Cite this article as:

Qianhua Zhao, Qihao Guo, Xiaoniu Liang, Meirong Chen, Yan Zhou, Ding Ding and Zhen Hong , Auditory Verbal Learning Test is Superior to Rey-Osterrieth Complex Figure Memory for Predicting Mild Cognitive Impairment to Alzheimer’s Disease, Current Alzheimer Research 2015; 12 (6) . https://dx.doi.org/10.2174/1567205012666150530202729