摘要
孕酮受体膜组分1和2，neudesin和neuferricin均属于膜孕激素受体（MAPR）家庭。最近，性类固醇膜受体因为潜在参与了性激素介导的快速非基因组的效应已获得了关注，目前尚不能解释核受体的基因组作用。孕酮可能通过包括丝裂原活化蛋白激酶的活化（MAPK）以及通过MAPRs的磷脂酰肌醇3激酶（PI3K）通路的非基因组效应来增加细胞的增殖和存活。此外，MAPRs独特的表达表明它们可能被用来作为生物标志物以及与性激素有关的癌症和其他疾病的药物靶点。在这篇综述中，我们总结了MAPRs的生理作用，提供一个全面的概述，关于他们的孕激素介导的非基因组作用的新见解，并讨论了其潜在的治疗靶点。
关键词: 孕酮；PGRMC1； PGRMC2；neudesin；neuferricin；癌症。
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