Recent Concise Viewpoints of Chronic Active Epstein-Barr Virus Infection

Title:Recent Concise Viewpoints of Chronic Active Epstein-Barr Virus Infection

Volume: 11 Issue: 1

Author(s): Motohiko Okano

Affiliation:

Keywords: CAEBV, T cell, NK cell or B cell LPD, HSCT.

Abstract: Chronic active Epstein-Barr virus infection (CAEBV) is characterized mainly by prolonged or intermittent fever, lymphadenopathy and hepatosplenomegaly without definite underlying diseases at the diagnosis. Patients with CAEBV also may have various life-threatening conditions including hematological, neurological, pulmonary, cardiac, digestive tract, ocular and/or dermal disorders. Additionally, during the course of illness, they often develop hematological malignancies such as T cell, NK cell or B cell lymphoproliferative disorder (LPD) and/or lymphoma. No causative pathogenetic mechanisms have been sufficiently clarified, and additionally no promising efficacious treatment was demonstrated except for the hematopoietic stem cell transplantation (HSCT) in cases who develop T cell or NK cell LPD or lymphoma. This minireview outlines the recent development for the comprehensive viewpoints of CAEBV mainly regarding to virological, immunological, pathological and therapeutical progresses.

Cite this article as:

Okano Motohiko, Recent Concise Viewpoints of Chronic Active Epstein-Barr Virus Infection, Current Pediatric Reviews 2015; 11 (1) . https://dx.doi.org/10.2174/1573396311666150501002809