摘要
血栓闭塞性脉管炎(TAO)指的是血栓闭塞性和病因不明的炎性外周动脉疾病。血栓性事件可以导致TAO患者丧失肢体能力,此通常是发生在社会经济地位低的年轻男性的身上。其初始过程是否为血栓形成或者是炎症这还是未知的,因此很难确定是否炎症或血栓形成的管理改善疾病治疗的结果。在这篇综述中,对TAO中可能的血栓形成的机制进行了阐述,其处理方法是对于TAO中血栓形成的机制以讨论为主,对二者进行阐述之外也对TAO管理所面临的挑战及与之相关的局限性进行了讨论。
关键词: 血栓闭塞性脉管炎, 一氧化氮,血栓闭塞性脉管炎,溶栓,血栓症,治疗
Current Medicinal Chemistry
Title:Mechanisms of Thrombosis, Available Treatments and Management Challenges Presented by Thromboangiitis Obliterans
Volume: 22 Issue: 16
Author(s): Bahare Fazeli and Hassan Ravari
Affiliation:
关键词: 血栓闭塞性脉管炎, 一氧化氮,血栓闭塞性脉管炎,溶栓,血栓症,治疗
摘要: Thromboangiitis obliterans (TAO) is a thrombotic-occlusive and an inflammatory peripheral arterial disease with unidentified aetiology. Thrombotic events can lead to limb loss in TAO patients, who are typically young male smokers of low socioeconomic status. It is still unknown whether the initial process is thrombosis or inflammation, so it is difficult to ascertain whether managing inflammation or thrombosis improves the outcome of the disease. In this review, the possible mechanisms of thrombosis in TAO are evaluated; the treatments, based on the discussed mechanisms of thrombosis in TAO, are then reviewed and the challenges and limitations associated with the management of TAO are discussed.
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Cite this article as:
Bahare Fazeli and Hassan Ravari , Mechanisms of Thrombosis, Available Treatments and Management Challenges Presented by Thromboangiitis Obliterans, Current Medicinal Chemistry 2015; 22 (16) . https://dx.doi.org/10.2174/0929867322666150429112111
DOI https://dx.doi.org/10.2174/0929867322666150429112111 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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