激酶锚定蛋白作为治疗疾病的蛋白质相互作用的药理干预策略

Title:Pharmacological Interference With Protein-protein Interactions of Akinase Anchoring Proteins as a Strategy for the Treatment of Disease

Volume: 17 Issue: 10

Author(s): Veronika A. Deák and Enno Klussmann

Affiliation:

关键词: AKAP；蛋白质-蛋白质相互作用；分割的cAMP信号；信号肽；模拟物；PKA；小分子。

摘要: A-kinase anchoring proteins (AKAPs) control the localization of cAMP-dependent protein kinase A (PKA) by tethering PKA to distinct cellular compartments. Through additional direct proteinprotein interactions with PKA substrates and other signaling molecules they form multi-protein complexes. Thereby, AKAPs regulate the access of PKA to its substrates in a temporal and spatial manner as well as the local crosstalk of cAMP/PKA with other signaling pathways. Due to the increasing information on their molecular functioning and three-dimensional structures, and their emerging roles in the development of diseases, AKAPs move into the focus as potential drug targets. Targeting AKAP dependent protein-protein interactions for interference with local signal processing inside cells potentially allows for the development of therapeutics with high selectivity and fewer side effects.

Cite this article as:

Veronika A. Deák and Enno Klussmann , Pharmacological Interference With Protein-protein Interactions of Akinase Anchoring Proteins as a Strategy for the Treatment of Disease, Current Drug Targets 2016; 17 (10) . https://dx.doi.org/10.2174/1389450116666150416114247