摘要
结直肠癌（CRC）是世界上最常见的癌症之一.。在过去的十年中，靶向治疗的发展给了转移性结直肠癌（mCRC）管理的一个癌症治疗新方向，并丰富了本病管理的治疗设备。在mCRC中，基于bevacizumab在临床试验中带来的最受欢迎的生存受益，通过血管内皮生长因子（VEGF）途径进行靶向的血管再生术已经引起了人们特别关注。最近，大型III期试验表明新抗血管增生药物aflibercept和regorafenib有临床效果 。然而，其它抗血管增生药物的临床前与临床研究结果却令人失望。 此外，血管增生抑制剂（AIs）在未筛选病人人群中表现出了温和这一优点。因此，深入研究预测生物标记物是必要的，但是到目前为止都失败了。然而，aflibercept和regorafenib被证明有益于bevacizumab单纯性和难治性病人，可能会反转AIs的获得性耐药性。这篇综述描述了mCRC中AIs发展的最近进展，特别关注了aflibercept和regorafenib，临床试验中这些药物评价所存在的挑战和设计发现临床有意义的生物标记物临床试验的潜在战略。
关键词: 结直肠癌，血管再生术，血管增生抑制剂，生物标记物，血管内皮生长因子（VEGF），bevacizumab
Call for Papers in Thematic Issues
Drug-Targeted Approach with Polymer Nanocomposites for Improved Therapeutics
Polymer nanocomposites have been recognized as an advanced and cutting-edge technique in drug targeting administration. These materials combine the unique features of nanoparticles with the adaptability of polymers to produce highly personalized drug administration devices. Integrating nanoparticles containing pharmaceuticals into a polymer matrix enables researchers to regulate the rates at ...read more
New drug therapy for eye diseases
Eyesight is one of the most critical senses, accounting for over 80% of our perceptions. Our quality of life might be significantly affected by eye disease, including glaucoma, diabetic retinopathy, dry eye, etc. Although the development of microinvasive ocular surgery reduces surgical complications and improves overall outcomes, medication therapy is ...read more
Therapeutic Chemical and RNA Design with Artificial Intelligence
Computer-Aided Drug Design (CADD) has emerged as a fundamental component of modern drug discovery. Molecular docking facilitates virtual screening on a large scale through structural simulations. However, traditional CADD approaches face significant limitations, as they can only screen known compounds from existing libraries. PubChem, as the most widely used chemical ...read more
Related Journals
Anti-Cancer Agents in Medicinal Chemistry
Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry
Current Bioactive Compounds
Current Cancer Drug Targets
Combinatorial Chemistry & High Throughput Screening
Current Cancer Therapy Reviews
Current Diabetes Reviews
Current Drug Safety
Current Drug Therapy
Current Drug Delivery
Related Books
Anthocyanins: Pharmacology and Nutraceutical Importance
Computer-Aided Drug Discovery Methods: A Brief Introduction
The Roles and Responsibilities of Clinical Pharmacists in Hospital Settings
Bioactive Compounds from Medicinal Plants for Cancer Therapy and Chemoprevention
Drug Addiction Mechanisms in the Brain
Software and Programming Tools in Pharmaceutical Research
Objective Pharmaceutics: A Comprehensive Compilation of Questions and Answers for Pharmaceutics Exam Prep
Medicinal Chemistry of Drugs Affecting Cardiovascular and Endocrine Systems
Medicinal Plants, Phytomedicines and Traditional Herbal Remedies for Drug Discovery and Development against COVID-19
Advanced Pharmacy
113
4
