Adiponectin as a Target in Obesity-related Inflammatory State

Title:Adiponectin as a Target in Obesity-related Inflammatory State

Volume: 15 Issue: 2

Author(s): Koji Ohashi, Daisuke Yuasa, Rei Shibata, Toyoaki Murohara and Noriyuki Ouchi

Affiliation:

Keywords: Adiponectin, cardiovascular disease, cerebrovascular disease, CKD, inflammation, insulin resistance, NASH.

Abstract: Accumulating evidence indicates that low grade inflammation is closely associated with obesity-related disorders including type 2 diabetes, hypertension and atherosclerosis. Adiponectin is a fat-derived plasma protein with anti-inflammatory functions. Circulating levels of adiponectin are decreased in obese states, and these conditions are broadly associated with various obesity-related diseases. Furthermore, adiponectin has direct protective functions against cardiovascular disease, cerebrovascular disease, non-alcoholic steatohepatitis (NASH) and chronic kidney disease (CKD). In this review, we will focus on the protective functions of adiponectin against these obesity-related diseases from the view point of its anti-inflammatory properties.

Cite this article as:

Ohashi Koji, Yuasa Daisuke, Shibata Rei, Murohara Toyoaki and Ouchi Noriyuki, Adiponectin as a Target in Obesity-related Inflammatory State, Endocrine, Metabolic & Immune Disorders - Drug Targets 2015; 15 (2) . https://dx.doi.org/10.2174/1871530315666150316122709