摘要
生物钟存在于大多数生物体中用以协调生活节奏的生理和行为。一般的分子机制是基于互锁转录-翻译反馈回路驱动的一系列核心时钟基因的基因表达节奏。多层调节包括转录,转录后和翻译后的机制使得比原来认为的生物钟调控更加复杂。尤其是,累积的证据表明,miRNA在调节生物钟功能的各个方面扮演着重要的角色。这篇综述,我们将总结最近的一些关于miRNAs与哺乳动物生物钟的相互作用的发现,并讨论miRNAs在健康和疾病状态下的生理节奏方面的相关研究前景。
关键词: 生物钟,生理动态,生理输出,微小RNA,后转录调节
Current Medicinal Chemistry
Title:The Crosstalk Between miRNA and Mammalian Circadian Clock
Volume: 22 Issue: 13
Author(s): Xia Wang, Guihua Tian, Zhongfeng Li and Lei Zheng
Affiliation:
关键词: 生物钟,生理动态,生理输出,微小RNA,后转录调节
摘要: Circadian clocks are present in most organisms to coordinate daily rhythms in physiology and behavior. The general molecular mechanisms are based on interlocked transcription-translation feedback loops driving rhythms in gene expression of a series of core clock genes. Multiple levels of regulations including transcriptional, posttranscriptional and post-translational mechanisms make circadian clock regulation more complex than once thought. Particularly, accumulating evidences have shown that miRNAs are significant players in regulating various aspects of circadian clock function. In this review, we will summarize the recent findings in the interplay of miRNAs and mammalian circadian clock and discuss future perspectives for research on the role of miRNAs played in circadian timing in health and disease.
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Cite this article as:
Xia Wang, Guihua Tian, Zhongfeng Li and Lei Zheng , The Crosstalk Between miRNA and Mammalian Circadian Clock, Current Medicinal Chemistry 2015; 22 (13) . https://dx.doi.org/10.2174/0929867322666150227155009
DOI https://dx.doi.org/10.2174/0929867322666150227155009 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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