脂质纳米载体（LNC）和它们在眼部药物投递中的应用

Title:Lipid Nanocarriers (LNC) and their Applications in Ocular Drug Delivery

Volume: 22 Issue: 13

Author(s): Carmelo Puglia, Alessia Offerta, Claudia Carbone, Francesco Bonina, Rosario Pignatello and Giovanni Puglisi

Affiliation:

关键词: 药物传递系统，脂质药物偶联物（LDC），纳米医学，纳米结构的脂质载体（NLC），眼科学，固体脂质纳米粒（SLN）

摘要: The peculiar physio-anatomical structure of the eye and the poor physico-chemical properties of many drug molecules are often responsible for the inefficient treatment of ocular diseases by conventional dosage forms, and justify the development of innovative ocular drug delivery systems. Lipid-based nanocarriers (LNC) are among the newer and interesting colloidal drug delivery systems; they show the capability to improve the local bioavailability of drugs administered by various ocular routes and, therefore, their therapeutic efficacy. Furthermore, their extreme biodegradability and biocompatible chemical nature have secured them the title of ‘nanosafe carriers.’ This review treats the main features of LNC [namely, solid lipid nanoparticles (SLN), nanostructured lipid carriers (NLC) and lipid-drug conjugates (LDC)]; examples and advantages of the application of these colloidal carrier systems for the ophthalmic administration of drugs are presented.

Cite this article as:

Carmelo Puglia, Alessia Offerta, Claudia Carbone, Francesco Bonina, Rosario Pignatello and Giovanni Puglisi , Lipid Nanocarriers (LNC) and their Applications in Ocular Drug Delivery, Current Medicinal Chemistry 2015; 22 (13) . https://dx.doi.org/10.2174/0929867322666150209152259