摘要
靶向药物的设计方法是一系列的计算过程，包括可视化工具，来支持药物设计和发现过程的决策系统。根据生物靶点形成的潜在靶点或药物分子的本质，这篇综述提出了靶向药物设计的不同的组成部分的定位，其中包括目标识别、蛋白建模、分子动力学、捆绑/催化位点识别、对接、虚拟筛选、碎片基础策略、治疗靶点在应对耐药性的子结构、硅易位聚合、结构疫苗学等，及其中所涉及的关键问题和一些案例研究调查。这些概念和工作程序被用钻研眼光进行了讨论，并引起了关注，促进了药物研究。
关键词: 耐药性，同源建模，分子动力学，基于结构的药物设计，结构疫苗学，靶向药物设计，靶点识别，虚拟筛选
Call for Papers in Thematic Issues
Advances in Medicinal Chemistry: From Cancer to Chronic Diseases.
The broad spectrum of the issue will provide a comprehensive overview of emerging trends, novel therapeutic interventions, and translational insights that impact modern medicine. The primary focus will be diseases of global concern, including cancer, chronic pain, metabolic disorders, and autoimmune conditions, providing a broad overview of the advancements in ...read more
Approaches to the Treatment of Chronic Inflammation
Chronic inflammation is a hallmark of numerous diseases, significantly impacting global health. Although chronic inflammation is a hot topic, not much has been written about approaches to its treatment. This thematic issue aims to showcase the latest advancements in chronic inflammation treatment and foster discussion on future directions in this ...read more
Cellular and Molecular Mechanisms of Non-Infectious Inflammatory Diseases: Focus on Clinical Implications
The Special Issue covers the results of the studies on cellular and molecular mechanisms of non-infectious inflammatory diseases, in particular, autoimmune rheumatic diseases, atherosclerotic cardiovascular disease and other age-related disorders such as type II diabetes, cancer, neurodegenerative disorders, etc. Review and research articles as well as methodology papers that summarize ...read more
Chalcogen-modified nucleic acid analogues
Chalcogen-modified nucleosides, nucleotides and oligonucleotides have been of great interest to scientific research for many years. The replacement of oxygen in the nucleobase, sugar or phosphate backbone by chalcogen atoms (sulfur, selenium, tellurium) gives these biomolecules unique properties resulting from their altered physical and chemical properties. The continuing interest in ...read more
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