Abstract
Countless bioactive constituents obtained from different medicinal plants have long been focused by the researchers of the scientific community and pharmaceutical industry. In recent years, extensive in vitro and in vivo research has been carried out with these biomolecules to develop complementary and alternative medicines. Findings revealed that these molecules may act as promising agents for almost all kinds of pathophysiological states. Further, these novel bioactive compounds are mostly not harmful in dietary doses. In this eclectic review, we highlighted the beneficial role of genistein, an isoflavone available mainly in the legumes particularly in soybean. Genistein is a potent phytoestrogen which binds with both alpha and beta estrogen receptors and regulate the divergent intracellular signaling cascades of estrogen. It also has the potential to competitively inhibit different imperative ATP utilizing enzymes. These properties help genistein in regulating various cellular and biochemical functions at different levels of structural organization in the body. Moreover, it’s very low cytotoxicity and abundance in regular aliment compared to other isoflavones makes it a more promising therapeutic option. Emerging evidence from the literature proves the competence of genistein in combating oxidative stress, cancer, diabetes, obesity, inflammation, osteoporosis, neuropathy and some other disorders. This review aims to unravel the assorted underlying mechanisms behind the multivariate properties of this unique aglycone.
Keywords: Anticancer, antidiabetic, cytotoxicity, estrogen receptors, oxidative stress, pathophysiology, phytoestrogens.
Call for Papers in Thematic Issues
Bioprospecting of Natural Products as Sources of New Multitarget Therapies
According to the Convention on Biological Diversity, bioprospecting is the exploration of biodiversity and indigenous knowledge to develop commercially valuable products for pharmaceutical and other applications. Bioprospecting involves searching for useful organic compounds in plants, fungi, marine organisms, and microorganisms. Natural products traditionally constituted the primary source of more than ...read more
Computational Frontiers in Medicinal Chemistry
The thematic issue "Computational Frontiers in Medicinal Chemistry" provides a robust platform for delving into state-of-the-art computational methodologies and technologies that significantly propel advancements in medicinal chemistry. This edition seeks to amalgamate top-tier reviews spotlighting the latest trends and breakthroughs in the fusion of computational approaches, including artificial intelligence (AI) ...read more
Drugs and Mitochondria
Mitochondria play a central role in the life and death of cells. They are not merely the center for energy metabolism but are also the headquarters for different catabolic and anabolic processes, calcium fluxes, and various signaling pathways. Mitochondria maintain homeostasis in the cell by interacting with reactive oxygen-nitrogen species ...read more
Mitochondria as a Therapeutic Target in Metabolic Disorders
Mitochondria are the primary site of adenosine triphosphate (ATP) production in mammalian cells. Moreover, these organelles are an important source of reactive oxygen and nitrogen species in virtually any nucleated cell type. The modulation of a myriad of cellular signaling pathways depends on the mitochondrial physiology. Mitochondrial dysfunction is observed ...read more
Related Journals
Anti-Cancer Agents in Medicinal Chemistry
Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry
Current Bioactive Compounds
Current Cancer Drug Targets
Combinatorial Chemistry & High Throughput Screening
Current Cancer Therapy Reviews
Current Diabetes Reviews
Current Drug Safety
Current Drug Targets
Current Drug Therapy
Related Books
Herbs for Disease Prevention and Treatment
Anthocyanins: Pharmacology and Nutraceutical Importance
Therapeutic Insights into Herbal Medicine through the Use of Phytomolecules
The Roles and Responsibilities of Clinical Pharmacists in Hospital Settings
Bioactive Compounds from Medicinal Plants for Cancer Therapy and Chemoprevention
Science of Spices and Culinary Herbs - Latest Laboratory, Pre-clinical, and Clinical Studies
The Chemistry inside Spices & Herbs: Research and Development
The Chemistry inside Spices & Herbs: Research and Development
Drug Addiction Mechanisms in the Brain
Botanicals and Natural Bioactives: Prevention and Treatment of Diseases
70