摘要
这篇综述系统的审查了关于在多种癌症中热休克蛋白(Hsp)Hsp27、Hsp60、Hsp70和Hsp90的预后意义的文献和数据。我们的文献分析显示现有的数据对于Hsp的预后意义的描述相互矛盾。这种结果可能是由于癌症研究中存在的生理差异和在评估热休克蛋白时的方法学差异。因为它们高度表达从而使肿瘤细胞避免细胞凋亡而死亡,所以热休克蛋白在癌症发展过程中发挥着重要作用。因此,热休克蛋白的抑制目前是对抗癌症的一种有吸引力的潜在治疗方案。
关键词: 癌症,热休克蛋白,热休克蛋白27,热休克蛋白60,热休克蛋白70,热休克蛋白90,预后指标
Current Cancer Drug Targets
Title:Heat Shock Proteins as Prognostic Markers of Cancer
Volume: 14 Issue: 8
Author(s): Evgeniya V. Kaigorodova and Mariya V. Bogatyuk
Affiliation:
关键词: 癌症,热休克蛋白,热休克蛋白27,热休克蛋白60,热休克蛋白70,热休克蛋白90,预后指标
摘要: This review systematically examines the literature and data on the prognostic significance of heat shock proteins (heat shock protein - Hsp) Hsp27, Hsp60, Hsp70, Hsp90 in various cancers. Our analysis of the literature showed that the existing data are contradictory with regard to the prognostic significance of Hsp. This result may be due to biological differences of the carcinomas studied and methodological differences in the assessment of heat shock proteins. Heat shock proteins play a significant role in the development of cancer, as they are highly expressed and thus allow tumor cells to escape apoptotic death. Therefore, the inhibition of Hsps is currently an attractive potential therapeutic approach against cancer.
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Cite this article as:
Kaigorodova V. Evgeniya and Bogatyuk V. Mariya, Heat Shock Proteins as Prognostic Markers of Cancer, Current Cancer Drug Targets 2014; 14 (8) . https://dx.doi.org/10.2174/1568009614666140926122846
DOI https://dx.doi.org/10.2174/1568009614666140926122846 |
Print ISSN 1568-0096 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-5576 |
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