Abstract
Intracranial aneurysms are present in 1-5% of population and can be described as “ticking time bombs” that can go off at any time and cause serious harms including permanent disability and death. There are two routinely practiced treatment options for this disease; endovascular coiling and surgical clipping. In recent years other promising methods, such as stent-assisted coiling, flow diverting devices and Onyx embolic agent, have also been developed and tested. The studies reviewed here suggest endovascular coiling to be the most commonly chosen treatment method and that there are reservations on using the newly developed techniques, despite studies suggesting their safety and effectiveness. Therefore, it is now becoming clear that a competent management system, in which treatment methods are chosen to best fit the characterisation of the patient and the aneurysm, should be developed in order to effectively diagnose and treat intracranial aneurysms. One way to develop such a system could be through the advancements of nanotechnology and smart materials. Neurosurgery, like many other areas of the medical field, is moving towards adopting the exciting and rapidly developing technologies based on nanomaterials as the nano-approach to detect and treat intracranial aneurysms could offer surgical opportunities that were more invasive or out of rich at the microneurosurgery level.
Keywords: Clipping, coiling, intracranial aneurysms, nanomedicine, nanoneurosurgery, nanotechnology.
Current Medicinal Chemistry
Title:Intracranial Aneurysms; In Need of Early Diagnostic and Treatment Using Bio- and Nanotechnology
Volume: 21 Issue: 37
Author(s): Shima Salmasi and Alexander Marcus Seifalian
Affiliation:
Keywords: Clipping, coiling, intracranial aneurysms, nanomedicine, nanoneurosurgery, nanotechnology.
Abstract: Intracranial aneurysms are present in 1-5% of population and can be described as “ticking time bombs” that can go off at any time and cause serious harms including permanent disability and death. There are two routinely practiced treatment options for this disease; endovascular coiling and surgical clipping. In recent years other promising methods, such as stent-assisted coiling, flow diverting devices and Onyx embolic agent, have also been developed and tested. The studies reviewed here suggest endovascular coiling to be the most commonly chosen treatment method and that there are reservations on using the newly developed techniques, despite studies suggesting their safety and effectiveness. Therefore, it is now becoming clear that a competent management system, in which treatment methods are chosen to best fit the characterisation of the patient and the aneurysm, should be developed in order to effectively diagnose and treat intracranial aneurysms. One way to develop such a system could be through the advancements of nanotechnology and smart materials. Neurosurgery, like many other areas of the medical field, is moving towards adopting the exciting and rapidly developing technologies based on nanomaterials as the nano-approach to detect and treat intracranial aneurysms could offer surgical opportunities that were more invasive or out of rich at the microneurosurgery level.
Export Options
About this article
Cite this article as:
Salmasi Shima and Seifalian Marcus Alexander, Intracranial Aneurysms; In Need of Early Diagnostic and Treatment Using Bio- and Nanotechnology, Current Medicinal Chemistry 2014; 21 (37) . https://dx.doi.org/10.2174/0929867321666140716103921
DOI https://dx.doi.org/10.2174/0929867321666140716103921 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
Call for Papers in Thematic Issues
Advances in Medicinal Chemistry: From Cancer to Chronic Diseases.
The broad spectrum of the issue will provide a comprehensive overview of emerging trends, novel therapeutic interventions, and translational insights that impact modern medicine. The primary focus will be diseases of global concern, including cancer, chronic pain, metabolic disorders, and autoimmune conditions, providing a broad overview of the advancements in ...read more
Approaches to the Treatment of Chronic Inflammation
Chronic inflammation is a hallmark of numerous diseases, significantly impacting global health. Although chronic inflammation is a hot topic, not much has been written about approaches to its treatment. This thematic issue aims to showcase the latest advancements in chronic inflammation treatment and foster discussion on future directions in this ...read more
Cellular and Molecular Mechanisms of Non-Infectious Inflammatory Diseases: Focus on Clinical Implications
The Special Issue covers the results of the studies on cellular and molecular mechanisms of non-infectious inflammatory diseases, in particular, autoimmune rheumatic diseases, atherosclerotic cardiovascular disease and other age-related disorders such as type II diabetes, cancer, neurodegenerative disorders, etc. Review and research articles as well as methodology papers that summarize ...read more
Chalcogen-modified nucleic acid analogues
Chalcogen-modified nucleosides, nucleotides and oligonucleotides have been of great interest to scientific research for many years. The replacement of oxygen in the nucleobase, sugar or phosphate backbone by chalcogen atoms (sulfur, selenium, tellurium) gives these biomolecules unique properties resulting from their altered physical and chemical properties. The continuing interest in ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Current Status and Prospective Application of Stem Cell-Based Therapies for Spinal Cord Injury
Current Stem Cell Research & Therapy The Simulation and Experimental Comparison of Parameter Factors Impact on MRI Artifact
Current Medical Imaging Problems and Perspectives of Abdominal Aortic Aneurysm Research
Current Drug Targets Is Hospital Autopsy Auditing Suitable for Clinical Risk Manage ment? Actualities and Perspectives of Auditing in the Autopsy Room Following Italian Law 24/2017 on Patient Safety
Current Pharmaceutical Biotechnology microRNAs in Stroke Pathogenesis
Current Molecular Medicine Development of Anti-Atherosclerosis Therapy Based on the Inflammatory and Proliferative Aspects of the Disease
Current Pharmaceutical Design Histone Methylation and Transcriptional Regulation in Cardiovascular Disease
Cardiovascular & Hematological Disorders-Drug Targets Matrix Metalloproteinases as Drug Targets in Preeclampsia
Current Drug Targets Platelet Toll-Like Receptor Expression: The Link Between “Danger” Ligands and Inflammation
Inflammation & Allergy - Drug Targets (Discontinued) Diagnosis and Management of Chronic Coronary Artery Disease
Current Cardiology Reviews Potential Interactions of Carotenoids with Other Bioactive Food Components in the Prevention of Chronic Diseases
Current Bioactive Compounds Patent Selections :
Recent Patents on Cardiovascular Drug Discovery Expression of Circulating miR-21 and -29 and their Association with Myocardial Fibrosis in Hypertrophic Cardiomyopathy
Current Medicinal Chemistry Vascular Risk Factors, Vascular Diseases, and Imaging Findings in a Hospital-based Cohort of Mild Cognitive Impairment Types
Current Alzheimer Research IgG4 Related Syndrome: Another Multiorgan Disease in the Interest Field of Internal Medicine
Current Pharmaceutical Design Regulation of Cell Migration and Invasion by Specific Modules of uPA: Mechanistic Insights and Specific Inhibitors
Current Drug Targets Hypertension in Pregnancy: A Review of Current Guidelines
Current Women`s Health Reviews A Direct Correlation between Red Blood Cell Indices and Cognitive Impairment After Aneurysmal Subarachnoid Hemorrhage (aSAH)
Current Neurovascular Research Current Understanding of In-stent Restenosis and the Potential Benefit of Drug Eluting Stents
Current Drug Targets - Cardiovascular & Hematological Disorders Meet Our Editorial Board Member
Current Gene Therapy