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ISSN (Print): 1381-6128
ISSN (Online): 1873-4286

Inflammatory-Mediated Injury and Repair in the Traumatically Injured Spinal Cord

Author(s): T. B. Jones, E. E. McDaniel and P. G. Popovich

Volume 11, Issue 10, 2005

Page: [1223 - 1236] Pages: 14

DOI: 10.2174/1381612053507468

Price: $65

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Abstract

Spinal cord trauma activates the immune system and elicits leukocyte recruitment to the site of injury. This increase in immunological activity contributes to acute lesion expansion over a period of days to weeks following the initial trauma. At the same time, inflammatory cells and mediators facilitate endogenous repair processes such as axonal sprouting and remyelination. Thus, to be effective, therapies that target the immune system must limit the destructive effects of neutrophil, macrophage and lymphocyte activation, while simultaneously preserving their reparative functions.

Keywords: inflammation, spinal cord injury, neuroprotection, immunology, pathology


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